The effects of adrenocorticotrophic hormone and an equivalent dose of cortisol on the serum concentrations of lipids, lipoproteins, and apolipoproteins
The effects of adrenocorticotrophic hormone and an equivalent dose of cortisol on the serum concentrations of lipids, lipoproteins, and apolipoproteins
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DOI：
10.1016/j.metabol.2006.04.001
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发表时间：
2006-08-01
影响因子：
9.8
通讯作者：
Arnadottir, Margret
中科院分区：
文献类型：
--
作者：
Berg, Anna-Lena;Rafnsson, Arnar Thor;Arnadottir, Margret
以往的研究表明，促肾上腺皮质激素（ACTH）在健康个体和不同类型的脂蛋白异常血症患者中具有很强的降脂作用。这种作用背后的机制尚未确定，其直接acth特异性也受到质疑。因此，进行了本研究。将30名健康年轻男性随机分为3组，每组大小相同：一组给予ACTH(1-24) 1 mg IM，每日4天，另一组给予皮质醇150 mg ID （50 mg tid）每日4天，对照组观察4天。分别于治疗或观察前后采集空腹血样。ACTH组血清胆固醇（12%,P < 0.05）、低密度脂蛋白胆固醇（24%,P < 0.01）和载脂蛋白（apo） B （31%, P < 0.01）浓度显著降低，皮质醇组和对照组无显著降低。统计分析证实，只有ACTH对载脂蛋白b有降低作用。相反，结果表明，在血清载脂蛋白E浓度的增加方面，治疗组之间的一致性。血清中甘油三酯、高密度脂蛋白胆固醇、载脂蛋白A和脂蛋白(A)的浓度变化不一致。主要结果是明确的：ACTH对含载脂蛋白b的血清浓度的降低作用不能归因于皮质醇。这些，结合先前的体外结果，表明acth特异性作用。(c) 2006爱思唯尔公司版权所有。
Previous studies have shown a strong lipid-lowering effect of adrenocorticotrophic hormone (ACTH) in healthy individuals and in patients with different kinds of dyslipoproteinemia. The mechanism behind this effect has not been established and its direct ACTH-specific nature has been questioned. Therefore, the present study was performed. Thirty healthy young males were randomized into 3 groups of equal size: one group received ACTH(1-24) 1 mg IM, daily for 4 days, another group was treated with cortisol 150 mg ID (50 mg tid) daily for 4 days, whereas a control group was observed for 4 days. Fasting blood samples were collected before and after treatment or observation. The serum concentrations of cholesterol (12%, P < .05), low-density lipoprotein cholesterol (24%, P < .01), and apolipoprotein (apo) B (31%, P < .01) decreased significantly in the ACTH group but not in the cortisol and control groups. The statistical workup confirmed that only ACTH had a lowering effect on the apo B-containing lipoproteins. In contrast, the results indicated conformity between the treatment groups with respect to increases in the serum apo E concentrations. There were inconsistent changes in the serum concentrations of the triglycerides, high-density lipoprotein cholesterol, apo A, and lipoprotein(a). The main results were clear: the lowering effect of ACTH on the serum concentration of apo B-containing lipoproteins could not be ascribed to cortisol. These, in combination with previous in vitro results, indicated art ACTH-specific effect. (c) 2006 Elsevier Inc. All rights reserved.