Toxicology and carcinogenesis study of senna in C3B6.129F1-Trp53 tm1Brd N12 haploinsufficient mice.
Toxicology and carcinogenesis study of senna in C3B6.129F1-Trp53 tm1Brd N12 haploinsufficient mice.
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DOI：
10.1177/0192623312464304
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发表时间：
2013-07
影响因子：
1.5
通讯作者：
Dunnick JK
中科院分区：
文献类型：
--
作者：
Surh I;Brix A;French JE;Collins BJ;Sanders JM;Vallant M;Dunnick JK
Senna is a pod or leaf of Senna alexandrina P. Mill and is used as a stimulant laxative. In the large intestine, bacterial enzymes break sennosides and release rhein-9-anthrone, the active form for the laxative effect. To determine potential toxic effects of senna, a 5-week dose range finding study in the C57BL/6N mouse and a 40-week toxicology and carcinogenesis study in the C3B6.129F1-Trp53tm1Brd N12 haploinsufficient (p53+/−) mouse were conducted. In the 5-week study, C57BL/6N mice were exposed up to 10,000 ppm senna in feed. Increased incidences of epithelial hyperplasia of the cecum and colon were observed in males and females exposed to 5,000 or 10,000 ppm senna. These intestinal lesions were not considered to be of sufficient severity to cause mortality and, thus, in the p53+/− mouse 40-week study, the high dose of 10,000 ppm was selected. Significant increases in the incidences of epithelial hyperplasia of the colon and cecum were observed at 10,000 ppm in p53(+/−) males and females, and the incidence of hyperplasia of the colon was significantly increased at 3,000 ppm in females. In conclusion, the large intestine was the major target of senna-induced toxicity in both wild-type and the p53+/− mouse model. There was no neoplastic change, when senna was administered to p53 +/− mouse.
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影响因子：
3.1
作者：
FRANZ, G
通讯作者：
FRANZ, G
影响因子：
64.8
作者：
DONEHOWER, LA;HARVEY, M;BRADLEY, A
通讯作者：
BRADLEY, A
影响因子：
12.4
作者：
Helin, T;MakinenKiljunen, S
通讯作者：
MakinenKiljunen, S
影响因子：
6.4
作者：
Hu, Y;Le Leu, RK;Young, GP
通讯作者：
Young, GP
影响因子：
5.5
作者：
Bryant-Waugh, Rachel;Turner, Hannah;Mehta, Rajnikant
通讯作者：
Mehta, Rajnikant