PENICILLIN-BINDING PROTEINS AND CELL-SHAPE IN ESCHERICHIA-COLI
PENICILLIN-BINDING PROTEINS AND CELL-SHAPE IN ESCHERICHIA-COLI
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DOI：
10.1038/254516a0
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发表时间：
1975-01-01
期刊：
影响因子：
64.8
通讯作者：
PARDEE, AB
中科院分区：
文献类型：
--
作者：
SPRATT, BG;PARDEE, AB
β-内酰胺类抗生素(青霉素类和头孢菌素类)作为细胞生长和分裂的探针引起了广泛的关注1，2。尽管人们对青霉素敏感酶和青霉素结合蛋白3进行了广泛的研究，但还没有明确的迹象表明这些成分中的任何一个在β-内酰胺类抗生素对细胞生长的影响中所起的作用。我们报告了一个微小的青霉素结合蛋白的鉴定，我们认为它是氨基青霉烷酸指定为FL1060(参考文献)的靶标。4)作用于影响大肠杆菌的形状。这是鉴定青霉素结合蛋白的第一个例子，青霉素结合蛋白在细菌细胞生长中具有重要和明确的作用。
β-LACTAM antibiotics (penicillins and cephalosporins) have attracted considerable attention as probes of cell growth and division1,2. Although extensive studies have been made on both penicillin-sensitive enzymes and penicillin binding proteins3, there has been no clear indication of the role of any of these components in the effects of β-lactam antibiotics on cell growth. We report the identification of a minor penicillin binding protein which we believe to be the target at which the amidinopenicillanic acid designated FL1060 (ref. 4) acts to affect the shape ofEscherichia coli. This is the first example of the identification of a penicillin binding protein with an essential and defined role in bacterial cell growth.