Stem-cell-based embryo models for fundamental research and translation.
Stem-cell-based embryo models for fundamental research and translation.
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用于基础研究和翻译的基于干细胞的胚胎模型。
DOI：
10.1038/s41563-020-00829-9
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发表时间：
2021-03
期刊：
影响因子：
41.2
通讯作者：
Lutolf MP
中科院分区：
文献类型：
--
作者：
Fu J;Warmflash A;Lutolf MP
尽管它很重要，但对人类发育早期阶段的了解一直受到可获得的人类样本的严重限制。最近干细胞衍生胚胎模型的出现，这是一个旨在利用干细胞构建体外模型来概括哺乳动物胚胎发育的新领域，为促进对人类发育的基本了解和促进生殖和再生医学的发展打开了令人兴奋的机会。本文以小鼠和人类胚胎为模型，对哺乳动物早期发育的现有知识进行了综述，并强调了它们的相似之处和关键区别。然后我们重点介绍现有的胚胎模型，这些模型模拟了小鼠和人类发育的不同方面。我们进一步讨论了用于控制多细胞相互作用和自组织的生物工程工具，这些工具对于这些模型的发展至关重要。最后，我们讨论了干细胞衍生胚胎模型的重要下一步和令人兴奋的未来机会，以进行基础发现和翻译。这篇综述着重介绍了最近干细胞衍生胚胎模型的出现，以及利用这些模型发展人类胚胎学、生殖和再生医学的机会。
Despite its importance, understanding the early phases of human development has been significantly limited by availability of human samples. The recent emergence of stem cell-derived embryo models, a new field aiming to use stem cells to construct in vitro models to recapitulate snapshots of the development of the mammalian conceptus, opens up exciting opportunities to promote fundamental understanding of human development and advance reproductive and regenerative medicine. This review provides a summary of the current knowledge of early mammalian development, using mouse and human conceptuses as models, and emphasizes their similarities and critical differences. We then highlight existing embryo models that mimic different aspects of mouse and human development. We further discuss bioengineering tools used for controlling multicellular interactions and self-organization critical for the development of these models. We conclude with a discussion of the important next steps and exciting future opportunities of stem cell-derived embryo models for fundamental discovery and translation. This Review highlights the recent emergence of stem cell-derived embryo models and opportunities of using these models for advancing human embryology and reproductive and regenerative medicine.
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影响因子：
21.3
作者：
Boroviak T;Loos R;Bertone P;Smith A;Nichols J
通讯作者：
Nichols J
影响因子：
5.9
作者：
Guo G;von Meyenn F;Santos F;Chen Y;Reik W;Bertone P;Smith A;Nichols J
通讯作者：
Nichols J
影响因子：
5.9
作者：
Daley GQ;Hyun I;Apperley JF;Barker RA;Benvenisty N;Bredenoord AL;Breuer CK;Caulfield T;Cedars MI;Frey-Vasconcells J;Heslop HE;Jin Y;Lee RT;McCabe C;Munsie M;Murry CE;Piantadosi S;Rao M;Rooke HM;Sipp D;Studer L;Sugarman J;Takahashi M;Zimmerman M;Kimmelman J
通讯作者：
Kimmelman J
影响因子：
64.8
作者：
Brons, I. Gabrielle M.;Smithers, Lucy E.;Vallier, Ludovic
通讯作者：
Vallier, Ludovic
影响因子：
7.7
作者：
Dong, Chen;Beltcheva, Mariana;Theunissen, Thorold W.
通讯作者：
Theunissen, Thorold W.