EPITHELIAL (E-) AND PLACENTAL (P-) CADHERIN CELL-ADHESION MOLECULE EXPRESSION IN BREAST-CARCINOMA
EPITHELIAL (E-) AND PLACENTAL (P-) CADHERIN CELL-ADHESION MOLECULE EXPRESSION IN BREAST-CARCINOMA
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DOI：
10.1002/path.1711690211
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发表时间：
1993-02-01
影响因子：
7.3
通讯作者：
MILLIS, RR
中科院分区：
文献类型：
--
作者：
RASBRIDGE, SA;GILLETT, CE;MILLIS, RR
在正常乳腺组织中发现了细胞间粘附分子的钙粘蛋白家族的两个成员：E-（上皮）钙粘蛋白存在于管腔细胞和肌上皮细胞中，而P-（胎盘）钙粘蛋白仅限于肌上皮细胞。实验证据表明，E-钙粘蛋白的缺失与体外恶性细胞侵袭力的增加有关，这促使我们通过免疫组化染色来检查乳腺癌中E-和P-钙粘蛋白的存在和分布。E-钙粘蛋白存在于所有检查的原位和侵袭性导管癌中，尽管它呈片状分布，染色强度也各不相同。然而，在83%的浸润性小叶癌和所有原位小叶癌中，E-钙粘蛋白表达完全丧失。在其余17%的浸润性小叶肿瘤，E-钙粘蛋白似乎有一个异常的分布在细胞膜上的可变表达的细胞质内。相反，所有良性乳腺腔上皮和25例导管型和小叶型癌均不存在P-钙粘蛋白。仅在1例小叶型癌中发现。我们认为E-cadherin介导的细胞-细胞粘附的丧失在小叶癌的特征性形态中起着重要作用。
Two members of the cadherin family of intercellular adhesion molecules are found in normal breast tissue: E-(epithelial) cadherin is present in both luminal and myoepithelial cells, whereas P-(placental) cadherin is confined to myoepithelium. There is experimental evidence that loss of E-cadherin is associated with increased invasiveness of malignant cells in vitro, which stimulated us to examine the presence and distribution of E- and P-cadherin in breast carcinomas by means of immunohistochemical staining.E-Cadherin was present in all in situ and invasive ductal carcinomas examined, although it had a patchy distribution and the staining was of variable intensity. However, in 83 per cent of invasive lobular carcinomas and all lobular carcinomas in situ there was complete loss of E-cadherin expression. In the remaining 17 per cent of invasive lobular tumours, E-cadherin appeared to have an abnormal distribution within the cytoplasm with variable expression on the cell membrane. P-Cadherin, by contrast, was absent from all benign breast luminal epithelium and 25 carcinomas of ductal and lobular type. It was found in only one carcinoma of lobular type. We suggest that loss of cell-cell adhesion mediated by E-cadherin plays a part in the characteristic morphology of lobular carcinomas.