HISTORY OF PRION PROTEIN GENE (PRNP) POLYMORPHISM IN SHEEP AND SCIENTIFIC FINDINGS
HISTORY OF PRION PROTEIN GENE (PRNP) POLYMORPHISM IN SHEEP AND SCIENTIFIC FINDINGS
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DOI：
10.15666/aeer/1804_51495173
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发表时间：
2020
影响因子：
0.7
通讯作者：
A. Iqbal;X. He;D. Yue;X. Liu;S. Memon;D. Xi;W. Deng
中科院分区：
文献类型：
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作者：
A. Iqbal;X. He;D. Yue;X. Liu;S. Memon;D. Xi;W. Deng
痒病基本上是一种原本欧洲国家特有的疾病，但从英国开始蔓延到世界各地，到达加拿大、南非、澳大利亚、新西兰等许多国家。瘙痒病是一种致命的朊病毒病，会导致神经系统的退化或以神经系统的退化为特征。它属于传染性海绵状脑病（TSE），感染绵羊和山羊等小型反刍动物。绵羊对经典瘙痒病的易感性或抗性受到 PRNP 密码子 136、154 和 171 的多态性的高度监督。在本次综述中，我们发现罗马尼亚、芬兰、意大利、斯洛伐克、德国、希腊、西班牙、波兰、土耳其、伊朗、巴西、英国、葡萄牙、匈牙利、奥地利和捷克共和国等国家的绵羊易患羊痒病，而巴基斯坦、中国、阿尔及利亚、西非、美国、布基纳法索和尼日尔等国家的羊则不易患此病。从这些研究中，我们可以清楚地得出结论，中国和巴基斯坦是绵羊对瘙痒症表现出更强抵抗力的国家。我们重点总结了绵羊中PRNP 136、154和171位点的多态性以及世界主要地区的一些重要发现。
Scrapie is basically a kind of disease that originally was specific to European countries, but from England it spread all over the world to Canada, South Africa, Australia, New Zealand and many other countries. Scrapie is a prion disease which is fatal and results in or can be characterized by the degeneration of the nervous system. It belongs to transmissible spongiform encephalopathies (TSEs) infecting small ruminants including sheep and goat. Sheep susceptibility or resistance to classical scrapie is highly supervised by the polymorphisms at codons 136, 154 and 171 of the PRNP. In this review, we found that countries like Romania, Finland, Italy, Slovakia, Germany, Greece, Spain, Poland, Turkey, Iran, Brazil, England, Portugal, Hungary, Austria, and Czech Republic, are susceptible to scrapie, while in Pakistan, China, Algeria, West Africa, America, Burkina Faso, and Niger are those countries where sheep are not susceptible to this disease. From these studies, we can clearly conclude that China and Pakistan are the countries where sheep show more resistance to scrapie. We focused to summarize the PRNP polymorphism at 136, 154, and 171 in sheep and some important findings in major parts of the world.