Association of maternal IgM concentrations above the median at 15–19 weeks of gestation and early preterm delivery
Association of maternal IgM concentrations above the median at 15–19 weeks of gestation and early preterm delivery
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妊娠 15-19 周时母亲 IgM 浓度高于中位数与早期早产的关联
DOI：
10.1016/s0140-6736(99)03781-2
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
N. Paneth
中科院分区：
文献类型：
--
作者：
C. Holzman;J. Jetton;R. Fisher;P. Senagore;Manju Mohan;N. Paneth
妊娠 15-19 周时采集的母体血清中 IgM 浓度高于中位数，与 29 周前分娩密切相关（比值比 15·6）。我们的结果表明，极早产病因中假定的炎症成分可能早在妊娠中期就引起可测量的母体体液反应。
IgM concentrations greater than the median in maternal serum collected at 15–19 weeks of pregnancy were strongly associated (odds ratio 15·6) with delivery before 29 weeks. Our results suggest that the postulated inflammatory component in the aetiology of very preterm delivery may elicit a measurable maternal humoral response as early as mid-trimester.