EFFECT OF VASOPRESSIN AND CYCLIC AMP ON PERMEABILITY OF ISOLATED COLLECTING TUBULES
EFFECT OF VASOPRESSIN AND CYCLIC AMP ON PERMEABILITY OF ISOLATED COLLECTING TUBULES
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DOI：
10.1152/ajplegacy.1966.211.1.255
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发表时间：
1966-01-01
影响因子：
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通讯作者：
BURG, MB
中科院分区：
文献类型：
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作者：
GRANTHAM, JJ;BURG, MB
本文测定了加压素和环磷酸腺苷（AMP）对离体灌流兔集合小管水和尿素通透性的影响。当加入到溶液中浸泡小管外部时，这些试剂有规律地增加了沿着渗透梯度的净吸水率和在不存在渗透梯度的情况下用THO [氚化水]测量的对水的扩散渗透率。当仅将加压素加入到浸浴细胞腔边缘的溶液中时，加压素无效。尽管水渗透性同时增加，但加压素或环3 ''，5 ''-AMP均未显著改变尿素渗透性。
The effect of vasopressin and cyclic 3'', 5'' -AMP [adenosine-monophosphate] on the permeability to water and urea of the isolated perfused rabbit collecting tubule was measured. When added to the solution bathing the outside of the tubule, these agents regularly increased both net water absorption along an osmotic gradient and the diffusional permeability to water as measured with THO [tridiated H2O] in the absence of an osmotic gradient. When added only to the solution bathing the luminal border of the cells, vasopressin was ineffective. Urea permeability was not significantly altered by either vasopressin or cyclic 3'', 5''-AMP despite simultaneous increases in water permeability.