Acute nicotine decreases, and chronic nicotine increases the expression of brain-derived neurotrophic factor mRNA in rat hippocampus
Acute nicotine decreases, and chronic nicotine increases the expression of brain-derived neurotrophic factor mRNA in rat hippocampus
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DOI：
10.1016/s0169-328x(00)00246-1
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发表时间：
2000-12-28
期刊：
影响因子：
--
通讯作者：
Rattray, M
中科院分区：
文献类型：
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作者：
Kenny, PJ;File, SE;Rattray, M
急性尼古丁给药（0.5 mg/kg i. p.）给药后2 h和24 h，海马齿状回、CA 3和CA 1亚区BDNF mRNA水平显著降低。然而，与7天的尼古丁治疗，耐受性开发的抑制作用的尼古丁对BDNF mRNA的表达和有一个显着的增加，BDNF的表达后2小时，在CA 1区的最后一次注射。这些数据表明，海马BDNF表达的变化可能参与尼古丁急性和慢性治疗后观察到的行为效应。(C)2000 Elsevier Science B. V.保留所有权利。
Acute nicotine administration (0.5 mg/kg i.p.) significantly decreased BDNF mRNA levels in dentate gyrus, CA3 and CA1 subfields of the rat hippocampus 2 h and 24 h after administration. However, with 7 days nicotine treatment, tolerance developed to the inhibitory effect of nicotine on BDNF mRNA expression and there was a significant increase in BDNF expression 2 h after the final injection in the CA1 region. These data suggests that changes in expression of hippocampal BDNF may be involved in the behavioural effects of nicotine observed after acute and chronic treatment. (C) 2000 Elsevier Science B.V. All rights reserved.