Adaptive changes in locomotor control after partial denervation of triceps surae muscles in the cat
Adaptive changes in locomotor control after partial denervation of triceps surae muscles in the cat
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DOI：
10.1111/j.1469-7793.2001.0299b.x
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发表时间：
2001-05-15
影响因子：
5.5
通讯作者：
Prochazka, A
中科院分区：
文献类型：
--
作者：
Gritsenko, V;Mushahwar, V;Prochazka, A
1.本研究旨在验证猫内侧腓肠肌（MG）牵张反射通路的增益在其协同肌外侧腓肠肌（LQ）、比目鱼肌（SOL）和跖肌（PL）失神经支配后增加的假说.在四只猫的MG，胫骨前（TA）和股外侧肌（VL）肌肉植入肌电图（EMG）电极。这些猫走在一排高架桩上，其中一些是弹簧加载的，可以在脚触地的那一刻被触发弹出，快速背屈脚。在MG中的预拉伸EMG活动以及背屈的短、中、长潜伏期反应在单侧去神经之前和之后进行比较：MG的短潜伏期和中潜伏期反应的扰动增加成比例的增加预拉伸EMC：在几天和几周后，部分去神经。这反对牵张反射增益的适应性增加独立于中枢产生的伸肌驱动。局部皮肤麻醉对部分失神经支配前后MG牵张反应的大小无明显影响.我们的结论是，预拉伸FMG活动，以及在MG：肌肉的牵拉反射大幅增加后，去神经的协同肌肉。这些数据与中枢运动驱动的适应性增加一致，引起更多的运动神经元活动，这反过来又导致了牵张反射大小的增加。
1. This report concerns a test of the hypothesis that gain in the stretch reflex pathway of cat medial gastrocnemius (MG) muscle during locomotion increases after denervation of its synergists, lateral gastrocnemius (LQ), soleus (SOL) and plantaris (PL) muscles.2. In four cats, MG, tibialis anterior (TA) and vastus lateralis (VL) muscles were implanted with electromyogram (EMG) electrodes. The cats walked on a row of elevated pegs, some of which were spring-loaded and could be triggered to pop up at the moment of foot touchdown, rapidly dorsiflexing the foot. Pre-stretch EMG activity in MG as well as short-, medium- and long latency responses to the dorsiflexions were compared before and after unilateral denervation of synergists:.3. Short- and medium-latency responses of MG to perturbations increased in proportion to the increase in pre-stretch EMC: in the days and weeks after partial denervation. This argues against an adaptive increase in stretch reflex gain independent of centrally generated extensor drive.4. Local anaesthesia of the skin of the paw did not significantly change the sizes of the stretch responses of MG before or after partial denervation.5. We conclude that pre-stretch FMG activity as well as stretch reflexes in MG: muscle increased substantially after denervation of synergistic muscles. The data were consistent with an adaptive increase in central locomotor drive, causing more motoneuronal activity, which in turn resulted in an increase in the size of stretch reflexes.