Decreased adiposity and enhanced glucose tolerance in shikonin treated mice.
Decreased adiposity and enhanced glucose tolerance in shikonin treated mice.
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DOI：
10.1002/oby.21263
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发表时间：
2015-11
期刊：
影响因子：
--
通讯作者：
Haj FG
中科院分区：
文献类型：
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作者：
Bettaieb A;Hosein E;Chahed S;Abdulaziz A;Kucera HR;Gaikwad NW;Haj FG
肥胖症代表了一个主要的公共健康问题，并且鉴定调节能量平衡和葡萄糖稳态的天然化合物对于对抗肥胖症及其相关病症是有意义的。醌型紫草素具有多种有益作用，包括抗炎、抗氧化和抗微生物作用。本研究的目的是探讨紫草素对肥胖和葡萄糖稳态的影响。为此，我们确定了紫草素治疗对正常饮食或高脂饮食（HFD）激发的小鼠的代谢影响。紫草素治疗的小鼠喂养正常的食物表现出改善葡萄糖耐量。此外，紫草素处理的小鼠喂养HFD显示体重增加减少和抵抗HFD诱导的葡萄糖耐受不良。此外，紫草素治疗减少HFD诱导的肝血脂异常。这些发现与紫草素处理的喂食常规食物或HFD的小鼠中增强的肝脏胰岛素信号传导相关，如胰岛素受体的酪氨酰磷酸化增加和下游信号传导增强所证明的。这些研究确定紫草素作为体内系统性糖耐量、能量平衡和肥胖的潜在调节剂。
Obesity represents a major public health problem and identifying natural compounds that modulate energy balance and glucose homeostasis is of interest for combating obesity and its associated disorders. The naphthoquinone shikonin has diverse beneficial properties including anti-inflammatory, anti-oxidant and anti-microbial effects. The objective of this study is to investigate the effects of shikonin on adiposity and glucose homeostasis. To that end, we determined the metabolic effects of shikonin treatment on mice fed regular chow or challenged with a high fat diet (HFD). Shikonin treated mice fed regular chow exhibited improved glucose tolerance. In addition, shikonin treated mice fed HFD displayed decreased weight gain and resistance to HFD-induced glucose intolerance. Further, shikonin treatment decreased HFD-induced hepatic dyslipidemia. These findings correlated with enhanced hepatic insulin signaling in shikonin treated mice fed regular chow or HFD as evidenced by increased tyrosyl phosphorylation of the insulin receptor and enhanced downstream signaling. These studies identify shikonin as a potential regulator of systemic glucose tolerance, energy balance and adiposity in vivo.