Comparative analyses between Lolium/Festuca introgression lines and rice reveal the major fraction of functionally annotated gene models is located in recombination-poor/very recombination-poor regions of the genome
Comparative analyses between Lolium/Festuca introgression lines and rice reveal the major fraction of functionally annotated gene models is located in recombination-poor/very recombination-poor regions of the genome
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DOI：
10.1534/genetics.107.075515
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发表时间：
2007-09-01
期刊：
影响因子：
3.3
通讯作者：
King, Ian P.
中科院分区：
文献类型：
--
作者：
King, Julie;Armstead, Ian P.;King, Ian P.
水稻基因组序列的公布使得人们能够深入分析单子叶植物模式物种的基因组结构。这提供了一个强大的工具，在大基因组的未测序的农业重要的单子叶植物物种，如小麦，大麦，黑麦，黑麦草等基因组分析。以前的数据表明，大基因组单子叶植物中的大多数基因位于染色体的末端，在基因丰富的区域，经历高频率的重组。在这里，我们表明，在单子叶植物的编码序列的一个重要组成部分是本地化近端的区域非常低，甚至可以忽略不计的重组频率。我们的研究结果的影响是，在驯化的单子叶植物物种选择集中在基因位于染色体的末端区域内的重组频率高的地区。因此，可用于选择上级植物基因型的大部分遗传变异尚未被利用。此外，我们的研究结果提出了大型超基因复合体进化发展的可能性，这些复合体赋予个体选择优势。
Publication of the rice genome sequence has allowed an in-depth analysis of genome organization in a model monocot plant species. This has provided a powerful tool for genome analysis in large-genome unsequenced agriculturally important monocot species such as wheat, barley, rye, Lolium, etc. Previous data have indicated that the majority of genes in large-genome monocots are located toward the ends of chromosomes in gene-rich regions that undergo high frequencies of recombination. Here we demonstrate that a substantial component of the coding sequences in monocots is localized proximally in regions of very low and even negligible recombination frequencies. The implications of our findings are that during domestication of monocot plant species selection has concentrated on genes located in the terminal regions of chromosomes within areas of high recombination frequency. Thus a large proportion of the genetic variation available for selection of superior plant genotypes has not been exploited. In addition our findings raise the possibility of the evolutionary development of large supergene complexes that confer a selective advantage to the individual.