The metabolic consequences of childhood obesity
The metabolic consequences of childhood obesity
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DOI：
10.1016/j.beem.2005.04.009
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发表时间：
2005-09-01
影响因子：
7.4
通讯作者：
Caprio, S
中科院分区：
文献类型：
--
作者：
Weiss, R;Caprio, S
全球儿童肥胖症的患病率正在增加，这是与肥胖相关的共病的患病率。葡萄糖代谢改变，表现为糖耐量受损（IGT），在肥胖儿童和青少年中很早就出现。患有 IGT 的肥胖年轻人的特点是明显的外周胰岛素抵抗和相对的 P 细胞衰竭。肌肉和内脏室中的脂质沉积，而不仅仅是肥胖本身，与外周胰岛素抵抗增加有关，而外周胰岛素抵抗是代谢综合征的“驱动力”。代谢综合征的其他因素，例如血脂异常和高血压，已经存在于肥胖青少年中，并且随着肥胖程度的增加而恶化。同样，全身“低度炎症”的标志随着肥胖的增加而恶化。随着年轻人的成年，肥胖相关的胰岛素抵抗对心血管和肝脏发病率的长期影响预计会显现出来。
The prevalence of childhood obesity is increasing worldwide, is is the prevalence of obesity-related co-morbidity. Altered glucose metabolism, manifested as impaired glucose tolerance (IGT), appears early in obese children and adolescents. Obese young people with IGT are characterized by marked peripheral insulin resistance and a relative P-cell failure. Lipid deposition in muscle and the visceral compartment, and not only adiposity per se, is related to increased peripheral insulin resistance, the 'driving force' of the metabolic syndrome. Other elements of the metabolic syndrome, such as dyslipidemia and hypertension, are already present in obese youngsters and worsen with the degree of obesity. Similarly, markers of systemic 'low-grade inflammation' worsen with increasing adiposity. The long-term impact on cardiovascular and liver morbidity of obesity-related insulin resistance in young people is expected to emerge as these youngsters become young adults.