VARIANCES AND COVARIANCES OF SQUARED LINKAGE DISEQUILIBRIA IN FINITE POPULATIONS
VARIANCES AND COVARIANCES OF SQUARED LINKAGE DISEQUILIBRIA IN FINITE POPULATIONS
复制标题
DOI：
10.1016/0040-5809(88)90004-4
复制
发表时间：
1988-02-01
影响因子：
1.4
通讯作者：
WEIR, BS
中科院分区：
文献类型：
--
作者：
HILL, WG;WEIR, BS
对DNA序列中限制位点或碱基之间的连锁不平衡D的分析，源于有限群体中的突变，依赖于不同位点对之间的度量的方差-协方差结构的知识，例如D2。这需要评估两个、三个和四个基因座之间的基因频率的八阶矩，并在这里推导出必要的方法并计算结果。虽然主要强调突变或基因转换引起的不平衡，但该方法也考虑到只有漂移和重组的联合影响。数值结果证实，平方连杆不平衡可以有很高的方差和协方差。
Analysis of linkage disequilibrium D among restriction sites or bases in DNA sequences, arising from mutations in finite populations, depends on a knowledge of the variance-covariance structure of measures such as D2 between different pairs of sites. This requires evaluation of the eighth moments of gene frequencies among two, three, and four loci, and the necessary methodology is derived here and results are computed. While primary emphasis is placed on disequilibrium arising from mutation or gene conversion, the methodology also allows for the joint effects of only drift and recombination. Numerical results confirm that squared linkage disequilibria can have high variances and covariances.