Circadian Rhythm of Lipid Metabolism in Health and Disease
Circadian Rhythm of Lipid Metabolism in Health and Disease
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健康和疾病中脂质代谢的昼夜节律
DOI：
10.1002/smtd.201900601
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发表时间：
2020
期刊：
影响因子：
12.4
通讯作者：
Li Min-Dian
中科院分区：
文献类型：
--
作者：
Zhang Zhihui;Xin Haoran;Li Min-Dian
细胞功能的昼夜节律时间组织将化学不相容的过程隔离到一天中的不同时间。它是新兴的，脂质代谢的分子时间组织全天是至关重要的生理健身，功能障碍，这有助于目前流行性代谢疾病有关的脂质。在这里，目前的概念框架的生物钟系统和知识的昼夜节律的脂质代谢在不同的代谢组织和器官的健康和疾病进行了总结。最新进展的饮食和化学方法来调节昼夜节律的脂质和治疗人类疾病的影响也进行了审查。
The circadian temporal organization of cellular functions segregates chemically incompatible processes into different times of the day. It is emerging that the molecular temporal organization of lipid metabolism throughout the day is crucial for physiological fitness, the dysfunction of which contributes to current epidemic metabolic diseases related to lipids. Here, current conceptual frameworks of the circadian clock system and knowledge of the circadian rhythm of lipid metabolism in different metabolic tissues and organs in health and disease are summarized. Recent advances in dietary and chemical approaches to modulate the circadian rhythm of lipids and the implications to treating human diseases are also reviewed.