Magnetic particle imaging: advancements and perspectives for real-time in vivo monitoring and image-guided therapy
Magnetic particle imaging: advancements and perspectives for real-time in vivo monitoring and image-guided therapy
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DOI：
10.1039/c3nr00544e
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发表时间：
2013-01-01
期刊：
影响因子：
6.7
通讯作者：
Samia, Anna Cristina S.
中科院分区：
文献类型：
--
作者：
Pablico-Lansigan, Michele H.;Situ, Shu F.;Samia, Anna Cristina S.
磁颗粒成像（MPI）是一种新兴的生物医学成像技术，可以直接定量绘制超顺磁性氧化铁纳米颗粒的空间分布。MPI提高的灵敏度和较短的图像采集时间促进了具有高时间和空间分辨率的层析成像图像的创建。MPI的对比度和灵敏度有望超越目前使用的其他医学成像方式，如磁共振成像（MRI）、x射线扫描、超声、计算机断层扫描（CT）、正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）。在这篇综述中，我们介绍了在快速发展的MPI领域的最新进展。我们首先介绍了MPI的基本原理，然后是过去十年中用于改进这种新成像技术的策略和方法的一些亮点。我们还研究了用于成像的氧化铁纳米颗粒示踪剂的优化，强调了尺寸均匀性和表面工程的重要性。最后，我们提出了MPI的一些未来研究方向，强调了它作为实时体内监测的重要工具所提供的新颖和令人兴奋的机会。MPI提供的所有这些机会和能力现在被视为及时疾病诊断、植入物监测和图像引导治疗方面的潜在突破性创新。
Magnetic particle imaging (MPI) is an emerging biomedical imaging technology that allows the direct quantitative mapping of the spatial distribution of superparamagnetic iron oxide nanoparticles. MPI's increased sensitivity and short image acquisition times foster the creation of tomographic images with high temporal and spatial resolution. The contrast and sensitivity of MPI is envisioned to transcend those of other medical imaging modalities presently used, such as magnetic resonance imaging (MRI), X-ray scans, ultrasound, computed tomography (CT), positron emission tomography (PET) and single photon emission computed tomography (SPECT). In this review, we present an overview of the recent advances in the rapidly developing field of MPI. We begin with a basic introduction of the fundamentals of MPI, followed by some highlights over the past decade of the evolution of strategies and approaches used to improve this new imaging technique. We also examine the optimization of iron oxide nanoparticle tracers used for imaging, underscoring the importance of size homogeneity and surface engineering. Finally, we present some future research directions for MPI, emphasizing the novel and exciting opportunities that it offers as an important tool for real-time in vivo monitoring. All these opportunities and capabilities that MPI presents are now seen as potential breakthrough innovations in timely disease diagnosis, implant monitoring, and image-guided therapeutics.