Salmonella as a model for non-cognate Th1 cell stimulation.
Salmonella as a model for non-cognate Th1 cell stimulation.
复制标题
沙门氏菌作为非认知Th1细胞刺激的模型。
DOI：
10.3389/fimmu.2014.00621
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发表时间：
2014
影响因子：
7.3
通讯作者：
McSorley SJ
中科院分区：
文献类型：
--
作者：
O'Donnell H;McSorley SJ
Salmonella has been a model pathogen for examining CD4 T cell activation and effector functions for many years due to the strength of the Th1 cell response observed during Salmonella infections, the relative ease of use of Salmonella, the availability of Salmonella-specific T cell reagents, and the well-characterized nature of the model system, the pathogen, and the immune response elicited. Herein, we discuss the use of Salmonella as a model pathogen to explore the complex interaction of T cells with their inflammatory environment. In particular, we address the issue of bystander activation of naïve T cells and non-cognate stimulation of activated and memory T cells. Further, we compare and contrast our current knowledge of these non-cognate responses in CD8 versus CD4 T cells. Finally, we make a case for Salmonella as a particularly appropriate model pathogen in the study of non-cognate CD4 T cell responses based on the strength of the Th1 response during infection, the requirement for CD4 T cells in bacterial clearance, and the well-characterized inflammatory response to conserved molecular patterns induced by Salmonella infection.
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影响因子：
4.4
作者：
Cummings, LA;Barrett, SLR;Cookson, BT
通讯作者：
Cookson, BT
影响因子：
4.4
作者：
Cheminay, C;Möhlenbrink, A;Hensel, M
通讯作者：
Hensel, M
DOI：
10.1073/pnas.1203543109
发表时间：
2012-06-19
影响因子：
11.1
作者：
Freeman, Bailey E.;Hammarlund, Erika;Slifka, Mark K.
通讯作者：
Slifka, Mark K.
影响因子：
4.4
作者：
Bangs, Sarah C.;Baban, Dilair;Xu, Xiao-Ning
通讯作者：
Xu, Xiao-Ning
影响因子：
5.4
作者：
Di Genova, Gianfranco;Savelyeva, Natalia;Stevenson, Freda K.
通讯作者：
Stevenson, Freda K.