Neural activity induced by sensory stimulation can drive large-scale cerebrospinal fluid flow during wakefulness in humans.
Neural activity induced by sensory stimulation can drive large-scale cerebrospinal fluid flow during wakefulness in humans.
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DOI：
10.1371/journal.pbio.3002035
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发表时间：
2023-03
期刊：
影响因子：
9.8
通讯作者：
中科院分区：
文献类型：
--
作者：
脑脊液（CSF）流量维持健康的大脑稳态，促进溶质转运和大脑废物的交换。因此，脑脊液流动对大脑健康很重要，但控制其通过脑室大规模运动的机制还不清楚。虽然已经确定CSF流量受到呼吸和心血管动力学的调节，但最近的工作还表明，神经活动与睡眠期间脑室中的CSF流量的大波浪相关联。为了测试神经活动和CSF流量之间的时间耦合是否部分归因于因果关系，我们研究了CSF流量是否可以通过用强烈的视觉刺激驱动神经活动来诱导。我们用闪烁的棋盘视觉刺激操纵神经活动，发现我们可以驱动人脑中的宏观CSF流动。CSF流量的时间和幅度与视觉诱发的血流动力学反应相匹配，表明神经活动可以通过神经血管耦合来调节CSF流量。这些结果表明，神经活动可以有助于驱动人脑中的CSF流动，并且神经血管耦合的时间动力学可以解释这种效应。脑脊液在大脑周围流动，以清除其废物并保持大脑健康。这项研究表明，通过视觉刺激驱动神经活动可以快速诱导大规模的流体流动。脑血流动力学的变化可以解释这种模式，提供了一种非侵入性地操纵人类脑流体动力学的方法。
Cerebrospinal fluid (CSF) flow maintains healthy brain homeostasis, facilitating solute transport and the exchange of brain waste products. CSF flow is thus important for brain health, but the mechanisms that control its large-scale movement through the ventricles are not well understood. While it is well established that CSF flow is modulated by respiratory and cardiovascular dynamics, recent work has also demonstrated that neural activity is coupled to large waves of CSF flow in the ventricles during sleep. To test whether the temporal coupling between neural activity and CSF flow is in part due to a causal relationship, we investigated whether CSF flow could be induced by driving neural activity with intense visual stimulation. We manipulated neural activity with a flickering checkerboard visual stimulus and found that we could drive macroscopic CSF flow in the human brain. The timing and amplitude of CSF flow was matched to the visually evoked hemodynamic responses, suggesting neural activity can modulate CSF flow via neurovascular coupling. These results demonstrate that neural activity can contribute to driving CSF flow in the human brain and that the temporal dynamics of neurovascular coupling can explain this effect. Cerebrospinal fluid flows around the brain to remove its waste products and maintain brain health. This study shows that driving neural activity via visual stimulation can rapidly induce large-scale fluid flow. Changes in brain hemodynamics can explain this pattern, providing a way to non-invasively manipulate brain fluid dynamics in humans.
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DOI：
10.1093/brain/awaa443
发表时间：
2021-04-12
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Eide, Per Kristian;Vinje, Vegard;Ringstad, Geir
通讯作者：
Ringstad, Geir
影响因子：
3.3
作者：
Achermann, P;Borbely, AA
通讯作者：
Borbely, AA
影响因子：
5.7
作者：
Chen, Liyong;Beckett, Alexander;Feinberg, David A.
通讯作者：
Feinberg, David A.
DOI：
10.1038/jcbfm.2008.109
发表时间：
2009-01
期刊：
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
影响因子：
--
作者：
通讯作者：
--
影响因子：
5.7
作者：
Fischl, Bruce
通讯作者：
Fischl, Bruce