Suppression of lymphocyte responses by Actinobacillus actinomycetemcomitans.
Suppression of lymphocyte responses by Actinobacillus actinomycetemcomitans.
复制标题
伴放线放线杆菌对淋巴细胞反应的抑制。
DOI：
10.1111/j.1600-0765.1982.tb02027.x
复制
发表时间：
1982
影响因子：
3.5
通讯作者：
Taichman,NS
中科院分区：
文献类型：
--
作者：
Shenker,BJ;Tsai,CC;Taichman,NS
伴放线放线杆菌是一种革兰氏阴性菌，是青少年牙周炎的可疑病原体。这种淋巴细胞抑制活性的初步纯化和表征表明，它具有50，000的分子量，是热不稳定的和胰蛋白酶敏感的。此外，它似乎是与A中观察到的其他生物活性不同的部分。伴放线菌这些结果表明，从A.伴随放线菌能够抑制B和T细胞功能，这可能通过共同的机制介导。ie. T抑制细胞的激活。虽然牙周病的免疫机制还不清楚。
Actinobacillus actinomycetemcomitans is a gram-negative organism which is a suspected etiologic agent in juvenile periodontitis. Preliminary purification and characterization of this lymphocyte suppressive activity indicate that it has a molecular weight of 50,000, is heat labile, and trypsin sensitive. Furthermore, it appears to be a distinct moiety from other biological activities observed in A. actinomycetemcomitans sonicates. These results demonstrate that sonic extracts prepared from A. actinomycetemcomitans are capable of suppressing both B and T cell functions which may be mediated through a common mechanism. ie. the activation of T suppressor cells. Although the immunologic mechanism (s) involved in periodontal disease is not clearly defined.