Intrathymic islet transplantation in the spontaneously diabetic BB rat.
Intrathymic islet transplantation in the spontaneously diabetic BB rat.
复制标题
自发性糖尿病 BB 大鼠胸腺内胰岛移植。
DOI：
10.1097/00000658-199110000-00001
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发表时间：
1991
影响因子：
9
通讯作者：
Barker,CF
中科院分区：
文献类型：
--
作者：
Posselt,AM;Naji,A;Roark,JH;Markmann,JF;Barker,CF
最近研究表明，将胰岛同种异体移植物移植到化学诱导的糖尿病大鼠胸腺中不会产生排斥反应，并诱导对随后的胸腺外移植物的特异性无反应性。作者报道，胸腺也可以作为自发性糖尿病BB大鼠的有效胰岛移植部位，其中自身免疫和排斥反应可以破坏胰岛。胸腺内刘易斯胰岛移植物在这些大鼠中持续逆转高血糖超过120天，并且在四个接受者中的三个中，移植物促进了门静脉内胰岛的后续存活。相反，幼稚BB宿主的门静脉内胰岛同种异体移植物均迅速失败。作者还表明，胸腺的免疫豁免状态不能防止供体品系皮肤致敏的Wistar Furth（WF）大鼠中胰岛同种异体移植物的排斥反应，并且抑制细胞不太可能导致无反应状态，因为过继转移带有已建立的胸腺内刘易斯胰岛的WF大鼠的脾细胞未能延长胰岛同种异体移植物在第二宿主中的存活。图像
Recently it was demonstrated that pancreatic islet allografts transplanted to the thymus of rats made diabetic chemically are not rejected and induce specific unresponsiveness to subsequent extrathymic transplants. The authors report that the thymus can also serve as an effective islet transplantation site in spontaneously diabetic BB rats, in which autoimmunity and rejection can destroy islets. Intrathymic Lewis islet grafts consistently reversed hyperglycemia for more than 120 days in these rats, and in three of four recipients the grafts promoted subsequent survival of intraportal islets. In contrast intraportal islet allografts in naive BB hosts all failed rapidly. The authors also show that the immunologically privileged status of the thymus cannot prevent rejection of islet allografts in Wistar Furth (WF) rats sensitized with donor strain skin and that suppressor cells are not likely to contribute to the unresponsive state because adoptive transfer of spleen cells from WF rats bearing established intrathymic Lewis islets fails to prolong islet allograft survival in secondary hosts. Images