Gene transfer of vasoactive intestinal polypeptide into the penis improves erectile response in the diabetic rat
Gene transfer of vasoactive intestinal polypeptide into the penis improves erectile response in the diabetic rat
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DOI：
10.1111/j.1464-410x.2005.05422.x
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发表时间：
2005-04
影响因子：
4.5
通讯作者：
Zhou-jun Shen;Hua Wang;Ying-Li Lu;Xie-lai Zhou;Shan-wen Chen;Zhao-dian Chen
中科院分区：
文献类型：
--
作者：
Zhou-jun Shen;Hua Wang;Ying-Li Lu;Xie-lai Zhou;Shan-wen Chen;Zhao-dian Chen
目的探讨在STZ糖尿病大鼠阴茎海绵体中转染编码VIP的pcDNA3/血管活性肠多肽（vasoactive intestinal polypeptide， VIP） cDNA的可行性，阐明将VIP cDNA转染海绵体是否会影响海绵体神经刺激的生理反应，以及这一过程是否会影响糖尿病模型大鼠体内其他器官。
To determine the feasibility of transfecting penile corpora cavernosa with pcDNA3/vasoactive intestinal polypeptide (VIP) cDNA, which encodes for VIP in streptozotocin (STZ)‐diabetic rats, to clarify whether transfection of VIP cDNA into the cavernosum affects the physiological response to cavernosal nerve stimulation, and whether this process would affect other organs in the diabetic rat model in vivo.