Enhanced antimicrobial properties, cytocompatibility, and corrosion resistance of plasma-modified biodegradable magnesium alloys
Enhanced antimicrobial properties, cytocompatibility, and corrosion resistance of plasma-modified biodegradable magnesium alloys
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DOI：
10.1016/j.actbio.2013.10.012
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发表时间：
2014-01-01
影响因子：
9.7
通讯作者：
Chu, Paul K.
中科院分区：
文献类型：
--
作者：
Zhao, Ying;Jamesh, Mohammed Ibrahim;Chu, Paul K.
镁合金是一种潜在的生物可降解材料，由于其优异的生物性能和力学性能而受到越来越多的关注。然而，其在生理环境中的快速降解和潜在的毒性限制了其临床应用。近年来，化学成分具有生物相容性的特殊镁钙和镁锶合金已有报道，但其快速降解仍不能满足临床要求。为了提高镁-钙和镁-锶合金的耐蚀性，采用双注入法在镁-钙和镁-锶合金表面制备了一层粗糙疏水的含ZrO2的表面膜。失重测试和电化学腐蚀测试表明，经表面处理后的镁钙和镁锶合金的腐蚀速率明显降低。对改性后的二元镁合金的体外细胞响应和抗菌性能进行了系统研究。与未注入的对照相比，注入Zr-O和注入Zr的样品上的附着细菌数量显著减少。此外，从注入的样品中观察到显著增强了细胞的黏附和增殖。结果表明，锆氧离子双离子注入能有效提高镁钙和镁锶合金的耐腐蚀性、体外生物相容性和抗菌性能，为加速可生物降解镁合金的临床应用提供了一种简单实用的手段。(C)2013 Acta Materialia Inc.由Elsevier Ltd.出版。保留所有权利。
Magnesium alloys are potential biodegradable materials and have received increasing attention due to their outstanding biological performance and mechanical properties. However, rapid degradation in the physiological environment and potential toxicity limit clinical applications. Recently, special magnesium-calcium (Mg-Ca) and magnesium-strontium (Mg-Sr) alloys with biocompatible chemical compositions have been reported, but the rapid degradation still does not meet clinical requirements. In order to improve the corrosion resistance, a rough, hydrophobic and ZrO2-containing surface film is fabricated on Mg-Ca and Mg-Sr alloys by dual zirconium and oxygen ion implantation. Weight loss measurements and electrochemical corrosion tests Show that the corrosion rate of the Mg-Ca and Mg-Sr alloys is reduced appreciably after surface treatment. A systematic investigation of the in vitro cellular response and antibacterial capability of the modified binary magnesium alloys is performed. The amounts of adherent bacteria on the Zr-O-implanted and Zr-implanted samples diminish remarkably compared to the unimplanted control. In addition, significantly enhanced cell adhesion and proliferation are observed from the Zr-O-implanted sample. The results suggest that dual zirconium and oxygen ion implantation, which effectively enhances the corrosion resistance, in vitro biocompatibility and antimicrobial properties of Mg-Ca and Mg-Sr alloys, provides a simple and practical means to expedite clinical acceptance of biodegradable magnesium alloys. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.