Microwave-assisted direct biaryl coupling: first application to the synthesis of aporphines
Microwave-assisted direct biaryl coupling: first application to the synthesis of aporphines
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DOI：
10.1016/j.tetlet.2009.03.029
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发表时间：
2009-05-20
影响因子：
1.8
通讯作者：
Harding, Wayne W.
中科院分区：
文献类型：
--
作者：
Chaudhary, Sandeep;Pecic, Stevan;Harding, Wayne W.
我们研究了微波在直接联芳基偶联反应中的应用，合成了阿朴吗啡生物碱南丁宁的类似物。我们的研究表明，用这种方法可以快速地从苄基四氢异喹啉底物中获得阿朴吗啡核心。这是首次报道在微波辅助下合成阿朴吗啡分子的直接联芳基偶联反应。(C)2009爱思唯尔有限公司。保留所有权利。
We have investigated the use of microwaves in a direct biaryl Coupling reaction for the synthesis of analogs of the aporphine alkaloid nantenine. Our Study shows that the aporphine core may be rapidly accessed from benzyl-tetrahydroisoquinoline substrates with this method. This is the first report of a microwave-assisted direct biaryl coupling reaction in the synthesis of aporphine molecules. (C) 2009 Elsevier Ltd. All rights reserved.