Effects of multiple doses of the DPP-IV inhibitor PF-734200 on the relationship between GLP-1 and glucose in subjects with type 2 diabetes mellitus
Effects of multiple doses of the DPP-IV inhibitor PF-734200 on the relationship between GLP-1 and glucose in subjects with type 2 diabetes mellitus
复制标题
DOI：
10.1016/j.diabres.2010.10.018
复制
发表时间：
2011-02-01
影响因子：
5.1
通讯作者：
Calle, Roberto A.
中科院分区：
文献类型：
--
作者：
Gustavson, Stephanie M.;Dai, Haiqing;Calle, Roberto A.
一项随机、安慰剂对照研究评估了多剂量(28天)二肽基肽酶-IV(DPP-IV)抑制剂PF-734200对72例2型糖尿病患者的DPP-IV活性、血糖、胰高血糖素样肽-1(GLP-1)、胰升糖素和胰岛素水平的影响。餐后试验中活性GLP-1和血糖的变化之间的关系呈非线性。(C)2010爱思唯尔爱尔兰有限公司。保留所有权利。
A randomized, placebo-controlled study evaluated the effects multiple-doses ( 28 days) dipeptidyl peptidase-IV (DPP-IV) inhibitor PF-734200 on DPP-IV activity, glucose, glucagon-like peptide-1 (GLP-1), glucagon and insulin levels in 72 subjects with type 2 diabetes. The relationship between changes in active GLP-1 and glucose during a meal test appeared non-linear. (C) 2010 Elsevier Ireland Ltd. All rights reserved.