Neural correlate of subjective sensory experience gradually builds up across cortical areas
Neural correlate of subjective sensory experience gradually builds up across cortical areas
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DOI：
10.1073/pnas.0605826103
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发表时间：
2006-09-26
影响因子：
11.1
通讯作者：
Romo, Ranulfo
中科院分区：
文献类型：
--
作者：
de Lafuente, Victor;Romo, Ranulfo
当感觉刺激出现时，许多皮质区域被激活，但是在知觉判断过程中，感觉刺激的表征如何随时间并跨皮质区域演变？我们通过分析单个神经元的反应来研究这个问题，记录在顶叶和额叶的几个皮质区域，而训练有素的猴子报告是否存在施加到一个指尖皮肤的不同幅度的机械振动。在这里，我们表明，随着活动从初级体感皮层传递到额叶的运动前区，神经元活动和知觉判断之间的协变强度在整个皮质区域逐渐增加。这一发现表明，主观感觉体验的神经元相关性逐渐在顶叶的体感区域和额叶的运动前皮层中建立起来。
When a sensory stimulus is presented, many cortical areas are activated, but how does the representation of a sensory stimulus evolve in time and across cortical areas during a perceptual judgment? We investigated this question by analyzing the responses from single neurons, recorded in several cortical areas of parietal and frontal lobes, while trained monkeys reported the presence or absence of a mechanical vibration of varying amplitude applied to the skin of one fingertip. Here we show that the strength of the covariations between neuronal activity and perceptual judgments progressively increases across cortical areas as the activity is transmitted from the primary somatosensory cortex to the premotor areas of the frontal lobe. This finding suggests that the neuronal correlates of subjective sensory experience gradually build up across somatosensory areas of the parietal lobe and premotor cortices of the frontal lobe.