Effects of Tokishakuyakusan and its components on rat corpus luteum function in vitro.
Effects of Tokishakuyakusan and its components on rat corpus luteum function in vitro.
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时积药散及其成分对体外大鼠黄体功能的影响。
DOI：
10.1142/s0192415x88000042
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
S. Usuki
中科院分区：
文献类型：
--
作者：
S. Usuki
27日龄雌性大鼠接受20 IU PMS，56小时后接受40 IU hCG。hCG处理后7天，切除的卵巢用NIH-LH、Tokishakuyakusan（TJ-23）或其组分灌注。LH和TJ-23增加培养基中的孕酮，LH比TJ-23更有效。茯苓、芍药、泽泻和当归也能增加孕酮。TJ-23不刺激17 α-羟孕酮和20 α-羟孕酮。这些结果表明TJ-23刺激黄体分泌孕酮，而没有直接的促黄体或溶黄体作用，这种作用可能归因于茯苓、牡丹根、泽泻或日本当归根。
27-day-old female rats received 20 IU PMS and 56 hours later, 40 IU hCG. Seven days after hCG treatment, the resected ovaries were perifused with NIH-LH, Tokishakuyakusan (TJ-23) or its components. LH and TJ-23 increased progesterone in media and LH was more effective than TJ-23. Hoelen, Peony root, Alisma rhizome and Japanese angelica root also augmented progesterone. 17 alpha-hydroxyprogesterone and 20 alpha-hydroxyprogesterone were not stimulated by TJ-23. These results suggest that TJ-23 stimulates corpora lutea to secrete progesterone without direct luteotropic or luteolytic effect and that the effect may be attributable to Hoelen, Peony root, Alisma rhizome or Japanese angelica root.