Comparison of the effects of pilocarpine and cevimeline on salivary flow
Comparison of the effects of pilocarpine and cevimeline on salivary flow
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DOI：
10.1111/j.1601-5037.2008.00326.x
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发表时间：
2009-05-01
影响因子：
2.4
通讯作者：
Groppo, F. C.
中科院分区：
文献类型：
--
作者：
Braga, M. A.;Tarzia, O.;Groppo, F. C.
目的：比较小剂量匹罗卡品和西维美林对健康受试者唾液流量的影响。方法：在为期1周的交叉临床试验中，40名男性志愿者口服1%匹罗卡品(Salagen(TM))-60 mg kg(-1)体重(组1)或西维美林(Evoxac(TM))-30 mg(组2)。分别于用药前、用药后20、40、60、80、140和200min采集唾液样本，测定唾液流率(mlmin(-1))。此外，还在机械刺激下测定唾液分泌量，观察唾液腺功能。结果：资料经Friedman和Wilcoxon符号检验(显着性水平=5%)分析。匹罗卡品和西维美林在服药140min后唾液流量显著增加。在给药后140分钟和200分钟，西维米林的分泌量显著增加。不同受试者在机械刺激下的唾液腺功能没有差异。结论：两种药物均有增加健康受试者唾液流量的作用，但西维米林的疗效优于匹罗卡品。
Objective: The aim of the present study was to compare the effect of low-dose pilocarpine and cevimeline as stimulants for salivary flow in healthy subjects. Methods: In this cross-over clinical trial with a 1-week washout period, 40 male volunteers were submitted to an oral dose of pilocarpine 1% (Salagen (TM)) -60 mu g kg(-1) body-weight (Group 1) or Cevimeline (Evoxac (TM)) -30 mg (Group 2). Saliva samples were collected and the salivary flow rate was measured (ml min(-1)) at baseline and 20, 40, 60, 80, 140 and 200 min after administration of drugs. In addition, salivary secretion was also measured under mechanical stimulation to observe salivary gland function. Results: The data were analyzed by Friedman and Wilcoxon signed-rank tests (significance level = 5%). Pilocarpine and cevimeline significantly increased salivary flow 140 min after intake. There was a significant higher secretion with cevimeline 140 and 200 min after administration. There were no differences seen among subjects in the salivary glands function by mechanical stimulation. Conclusion: Both drugs showed efficacy in increasing the salivary flow in healthy volunteers, but cevimeline was more effective than pilocarpine.