Focal brain cooling terminates the faster frequency components of epileptic discharges induced by penicillin G in anesthetized rats
Focal brain cooling terminates the faster frequency components of epileptic discharges induced by penicillin G in anesthetized rats
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DOI：
10.1016/j.clinph.2012.02.074
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发表时间：
2012-09-01
影响因子：
4.7
通讯作者：
Suzuki, Michiyasu
中科院分区：
文献类型：
--
作者：
Kida, Hiroyuki;Fujii, Masami;Suzuki, Michiyasu
目的：本研究采用脑电图（EEG）频谱分析技术，观察局灶性脑冷却对麻醉大鼠感觉运动皮层癫痫放电（EDs）和背景节律的影响。使用连接到皮质表面的冷却装置实现局灶性脑冷却。皮层表面被冷却到25摄氏度、20摄氏度和15摄氏度，并且在冷却装置下方连续记录EEG。结果：青霉素G可引起ED，并使α和β功率谱增加。冷却抑制ED的效果取决于大脑温度。冷却到25 ℃衰减了β功率，冷却到20 ℃衰减了α和β功率，冷却到15 ℃抑制了从δ到β波段的光谱功率。结论：这些结果表明，局灶性脑冷却可以终止皮质中的ED，并抑制光谱功率，具有温度依赖性效应。这些发现可能有助于开发一种新的临床治疗癫痫患者。(C)2012年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: The goal of the study was to investigate the effects of focal brain cooling on epileptic discharges (EDs) and background rhythms in the sensorimotor cortex of anesthetized rats using spectral analysis of electroencephalography (EEG).Methods: Penicillin G was administered intracortically into superficial layers of the left sensorimotor cortex and EDs were induced. Focal brain cooling was achieved using a cooling device attached to the cortical surface. The cortical surface was cooled to 25 degrees C, 20 degrees C and 15 degrees C, and EEG was continuously recorded just beneath the cooling device. EEG spectral powers were determined using fast Fourier transform before and during cooling.Results: Penicillin G induced EDs and increased the Alpha and Beta power spectra. Cooling suppressed EDs with an effect that depended on the brain temperature. Cooling to 25 degrees C attenuated Beta powers, cooling to 20 degrees C attenuated Alpha and Beta powers, and cooling to 15 degrees C suppressed spectral powers ranging from Delta to Beta bands.Conclusions: These results suggest that focal brain cooling can terminate EDs in the cortex and suppress spectral powers with a temperature-dependent effect.Significance: These findings may contribute to development of a new clinical treatment for patients with epilepsy. (C) 2012 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.