SERUM-LIPIDS, LIPOPROTEIN ANALYSIS AND APOPROTEIN-A-I, APOPROTEIN-A-II AND APOPROTEIN-B LEVELS IN FRIEDREICHS ATAXIA
SERUM-LIPIDS, LIPOPROTEIN ANALYSIS AND APOPROTEIN-A-I, APOPROTEIN-A-II AND APOPROTEIN-B LEVELS IN FRIEDREICHS ATAXIA
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DOI：
10.1159/000117329
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发表时间：
1990-05-01
影响因子：
2.4
通讯作者：
CREPALDI, G
中科院分区：
文献类型：
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作者：
BALDOENZI, G;BERNARDO, M;CREPALDI, G
对15例弗里德赖希共济失调患者（男7例，女8例）进行血脂、脂蛋白及载脂蛋白参数测定。与对照组相比，患者的血脂水平无显著差异。血清磷脂、总HDL和HDL3胆固醇水平均有小幅下降，女性患者总胆固醇水平略有下降；血清载脂蛋白中，载脂蛋白B仅在男性中减少。最有趣的发现与脂蛋白有关，因为VLDL、LDL和HDL2部分的脂质和蛋白质质量都减少了。然而，在脂蛋白组成方面，HDL2是修改最多的部分，显示出重要的蛋白质减少。从这个角度来看，这种脂蛋白似乎对我们在患者中观察到的变化负有最大的责任。这种改变的脂蛋白模式在弗里德赖希共济失调的病理生理中的意义尚不清楚。
Serum lipid, lipoprotein and apoprotein parameters were evaluated in 15 patients (7 males and 8 females) with Friedreich''s ataxia. Serum lipid levels in patients showed no significant differences compared to controls. Small reduction in serum phospholipid and in total HDL and HDL3 cholesterol levels were observed, and the female patients presented a slight reduced total cholesterol level; among the serum apoproteins, apo B was reduced only in the males. The most interesting findings concerned the lipoproteins, since both lipid and protein masses of the VLDL, LDL and HDL2 fractions were reduced. In reference to lipoprotein composition, however, HDL2 was the most modified fraction, showing an important protein reduction. From this point of view, this lipoprotein seems the most responsible for the changes observed in our patients. The meaning of this modified lipoprotein pattern in the pathophysiology of Friedreich''s ataxia is not clear.