Safety of human olfactory mucosal biopsy for the purpose of olfactory ensheathing cell harvest and nerve repair: a prospective controlled study in patients undergoing endoscopic sinus surgery
Safety of human olfactory mucosal biopsy for the purpose of olfactory ensheathing cell harvest and nerve repair: a prospective controlled study in patients undergoing endoscopic sinus surgery
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DOI：
10.4193/rhino15.365
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发表时间：
2016-06-01
期刊：
影响因子：
7.2
通讯作者：
Choi, David
中科院分区：
文献类型：
--
作者：
Andrews, Peter J.;Poirrier, Anne-Lise;Choi, David
背景：鼻嗅粘膜是脊髓再生中可获得的嗅鞘细胞来源。然而，活检技术的安全性以及对嗅觉和鼻功能的影响尚未以前瞻性对照研究的形式得到强有力的评估。方法：131例患者的研究获得了国家卫生服务伦理批准。主要结局指标是嗅觉功能，次要结局包括术后并发症发生率、SNOT 22评分、NOSE评分和外科医生报告的（隆德-肯尼迪评分）鼻功能结局。结果：65例患者行功能性内窥镜鼻窦手术（FESS）和上鼻甲活检，66例患者仅行FESS作为对照组。两组患者并发症发生率无显著差异。嗅觉活检后，所有嗅觉功能结果均未受影响。我们证明，患者的生活质量和鼻通畅以及外科医生报告的结果测量在嗅觉采集后不受影响。结论：我们为鼻黏膜内镜活检的安全性提供了2a级的证据，与没有活检的标准FESS相比，鼻黏膜内镜活检不会影响鼻功能或嗅觉。
Background: Nasal olfactory mucosa is an accessible source of olfactory ensheathing cells for spinal cord regeneration. However, safety of the biopsy technique and the effects on sense of smell and nasal function have not been robustly assessed in the form of a prospective controlled study.Methodology: National Health Service ethical approval was granted for this study of 131 patients. The primary outcome measure was olfactory function and the secondary outcomes included postoperative complication rates as well as the SNOT 22, NOSE scale scores and surgeon reported (Lund-Kennedy score) nasal function outcomes.Results: 65 patients underwent functional endoscopic sinus surgery (FESS) and superior turbinate biopsy, and 66 patients underwent FESS only as the control group. There was no significant difference in complication rates between the two groups. All Olfactory function outcomes were unaffected following olfactory biopsy. We demonstrated that the patient's quality of life and nasal patency as well as surgeon reported outcome measurements remain unaffected following olfactory harvesting.Conclusions: We have uniquely provided level 2a evidence for the safety of endoscopic biopsy of olfactory mucosa, which does not affect nasal function or the sense of smell compared to standard FESS without biopsy.