Species differences of amobarbital metabolism: dihydroxyamobarbital formation.
Species differences of amobarbital metabolism: dihydroxyamobarbital formation.
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异戊巴比妥代谢的物种差异：二羟基异戊巴比妥的形成。
DOI：
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发表时间：
1980
影响因子：
2.1
通讯作者：
W. Kalow
中科院分区：
文献类型：
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作者：
B. Tang;A. Grey;P. Reilly;W. Kalow
阿莫巴比妥在动物和人体内几乎完全被代谢掉。主要代谢物是3′-羟基阿莫巴比妥。狗、小鼠、仓鼠、豚鼠和大鼠体内的第二大代谢物可鉴定为3′，4′-二羟基阿莫巴比妥。人和动物之间的一个显著对比是，人体内几乎不含二醇，而动物体内则不含氨巴比妥- n -葡萄糖苷。
Amobarbital is almost completely metabolized in animals and man. The major metabolite is 3'-hydroxyamobarbital. The second major metabolite in dog, mice, hamsters, guinea pigs, and rats could be identified as 3',4'-dihydroxyamobarbital. A striking contrast between man and animals is the virtual absence of the diol in man and absence of amobarbital-N-glucoside in animals.