Binding of heparin to human platelet factor 4.
Binding of heparin to human platelet factor 4.
复制标题
肝素与人血小板因子 4 的结合。
作者：
S. Cowan;E. N. Bakshi;K. Machin;N. Isaacs
血小板第4因子是一种来自血小板α颗粒的小蛋白(MR 7756)，它与肝素的抗凝特性有很强的结合，并能中和肝素的抗凝特性。通过对X射线结晶学数据的分析，提出了一个血小板因子4与肝素结合的模型。
Platelet factor 4 is a small protein (Mr 7756) from the alpha-granules of blood platelets which binds strongly to and neutralizes the anticoagulant properties of heparin. From an analysis of X-ray crystallographic data a model for the binding of platelet factor 4 to heparin is proposed.