CALCIUM-ANTAGONISTS IN MANIA - A DOUBLE-BLIND-STUDY OF VERAPAMIL
CALCIUM-ANTAGONISTS IN MANIA - A DOUBLE-BLIND-STUDY OF VERAPAMIL
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DOI：
10.1016/0165-1781(86)90016-8
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发表时间：
1986-08-01
影响因子：
11.3
通讯作者：
MURPHY, J
中科院分区：
文献类型：
--
作者：
DUBOVSKY, SL;FRANKS, RD;MURPHY, J
在一项双盲交叉研究中，7名急性躁狂患者中有5名在服用维拉帕米而不是安慰剂时有显著改善。这一发现支持了另外两项关于维拉帕米的正式研究，几项关于维拉帕米治疗躁狂患者的病例报告，以及一项关于硝苯地平的小型研究，该研究表明某些钙拮抗剂可能具有抗躁狂特性。间接证据表明，这种抗躁狂作用与情感障碍中细胞内钙动力学紊乱的纠正有关。然而，钙拮抗剂药物的有效性也可能与某些性质有关，而不是干扰脑神经元内钙的作用。
Five of seven acute manic patients improved significantly when taking verapamil but not placebo in a double-blind crossover study. This finding adds support to two other formal studies of verapamil, several case reports of verapamil in manic patients, and one small study of nifedipine suggesting that some calcium antagonists may have antimanic properties. Indirect evidence links this antimanic action to correction of a disturbance of intracellular calcium dynamics in affective disorders. However, the effectiveness of calcium antagonist drugs could also be related to some property other than interference with the action of calcium within brain neurons.