Serum Ferritin as Risk Factor for Veno-occlusive Disease of the Liver. Prospective Cohort Study.
Serum Ferritin as Risk Factor for Veno-occlusive Disease of the Liver. Prospective Cohort Study.
复制标题
血清铁蛋白是肝静脉闭塞性疾病的危险因素。
作者：
M. Morado;E. Ojeda;J. Garcia;M. Aguado;R. Arrieta;Emilio Quevedo;A. Navas;F. Hernández
肝静脉闭塞性疾病（VOD）是血液移植的重要并发症。本研究的目的是分析VOD和其他形式的肝毒性的危险因素，在我们中心进行的180例外周干细胞移植的队列。我们发现移植前血清铁蛋白水平升高是VOD最重要的危险标志。我们认为，铁蛋白反映了铁介导的催化导致的氧自由基诱导的损伤。我们还讨论了VOD和其他形式的肝毒性的不同危险因素，表明不同的致病机制。
Veno-occlusive disease of the liver (VOD) is an important complication in hematological transplantation. The aim of this study is to analyze the risk factors for VOD and other forms of liver toxicity in a cohort of 180 peripheral stem cell transplants performed in our Center. We find that elevated pretransplant levels of serum ferritin are the most important risk marker for VOD. We believe that ferritin reflects damage induced by oxygen radicals resulting from iron-mediated catalysis. We also discuss different risk factors for VOD and other forms of liver toxicity, suggesting diferent pathogenic mechanisms.
影响因子：
4.8
作者：
C. Rozman;E. Carreras;C. Qian;R. Gale;M. Bortin;P. Rowlings;R. Ash;R. Champlin;P. Henslee‐Downey;R. Herzig;W. Hinterberger;J. Klein;H. Prentice;J. Reiffers;F. Zwaan;M. Horowitz
通讯作者：
C. Rozman;E. Carreras;C. Qian;R. Gale;M. Bortin;P. Rowlings;R. Ash;R. Champlin;P. Henslee‐Downey;R. Herzig;W. Hinterberger;J. Klein;H. Prentice;J. Reiffers;F. Zwaan;M. Horowitz
影响因子：
4.8
作者：
H. Shulman;W. Hinterberger
通讯作者：
H. Shulman;W. Hinterberger