Statins are associated with reduced risk of gastric cancer: A meta-analysis
Statins are associated with reduced risk of gastric cancer: A meta-analysis
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DOI：
10.1007/s00228-013-1547-z
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发表时间：
2013-06
影响因子：
2.9
通讯作者：
Xiao-dan Wu;K. Zeng;Fang-Qin Xue;Jinhua Chen;Yan-qing Chen
中科院分区：
文献类型：
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作者：
Xiao-dan Wu;K. Zeng;Fang-Qin Xue;Jinhua Chen;Yan-qing Chen
背景他汀类药物被广泛用于降低胆固醇水平，预防动脉粥样硬化性心血管疾病。然而，关于他汀类药物对癌症风险影响的争论仍然悬而未决。本研究的目的是通过荟萃分析来探讨他汀类药物的使用与胃癌风险之间的关联。 方法在 PubMed 和 EMBASE 上进行截至 2013 年 3 月的文献检索，以确定检查他汀类药物使用与胃癌风险之间关系的队列或病例对照研究或随机对照试验 (RCT)。还审查了检索到的文章的参考书目，以确定更多的研究。使用随机效应模型来计算总相对风险 (RR)，置信区间 (CI) 为 95%。 结果 纳入了涉及 290 例胃癌的 26 项随机对照试验和总计 7,321 例胃癌的 8 项观察性研究的三项事后分析。研究显示，他汀类药物的使用与胃癌风险降低 27% 显着相关（RR = 0.73，95% CI = 0.58–0.93），研究之间存在相当大的异质性（I2= 88.9 %）。排除一项所有受试者均为糖尿病患者的研究，获得了减弱但均匀的结果（RR = 0.85，95% CI = 0.80–0.91，I2= 0.0 %）。这些发现在亚组分析中是一致的。结论对现有证据（主要来自观察性研究）的荟萃分析表明，使用他汀类药物可降低患胃癌的风险。
BackgroundStatins are widely prescribed to reduce cholesterol levels in the prevention of atherosclerotic cardiovascular disease. However, the debate about the effect of statins on cancer risk remains unsettled. The aim of this study was to investigate the association of utilization of statins with the risk of gastric cancer by carrying out a meta-analysis.MethodsA literature search was performed on PubMed and EMBASE up to March 2013 to identify the cohort or case–control studies or randomized controlled trials (RCTs) that examined the relationship between statins use and the risk of gastric cancer. The bibliographies of the retrieved articles were also reviewed to identify additional studies. A random-effects model was used to calculate the summary relative risks (RRs) with 95 % confidence intervals (CIs).ResultsThree post-hoc analyses of 26 RCTs involving 290 gastric cancers and eight observational studies totaling 7,321 gastric cancers were included. Statins use was shown to be significantly associated with a 27 % reduction in the risk of gastric cancer (RR = 0.73, 95 % CI = 0.58–0.93), with considerable heterogeneity among studies (I2= 88.9 %). Excluding one study in which all subjects are diabetic patients obtained an attenuated, but homogeneous result (RR = 0.85, 95 % CI = 0.80–0.91,I2= 0.0 %). These findings were consistent in the subgroup analysis.ConclusionA meta-analysis of existing evidence, primarily from observational studies, indicates that use of statins reduces the risk of gastric cancer.