Synthesis of polysubstituted 5-aminooxazoles from alpha-diazocarbonyl esters and alpha-isocyanoacetamides.
Synthesis of polysubstituted 5-aminooxazoles from alpha-diazocarbonyl esters and alpha-isocyanoacetamides.
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DOI：
10.1021/ol902850a
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发表时间：
2010-01
期刊：
影响因子：
5.2
通讯作者：
Jianwei Wu;Wenteng Chen;Miao Hu;H. Zou;Yongping Yu
中科院分区：
文献类型：
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作者：
Jianwei Wu;Wenteng Chen;Miao Hu;H. Zou;Yongping Yu
提出了一种合成2-酮基-5-氨基恶唑的新方法。整个序列通过简单地加热α-重氮羰基酯和α-异氰基乙酰胺的二甲苯溶液而无需任何促进剂来实现。提出了整个序列的可能机制。
A novel and efficient reaction for the synthesis of 2-keto-5-aminooxazoles is developed. The entire sequence is realized by simply heating a xylene solution of alpha-diazocarbonyl esters and alpha-isocyanoacetamides without any promoters. A possible mechanism for the entire sequence is proposed.