FUNCTION OF TORSO IN DETERMINING THE TERMINAL ANLAGEN OF THE DROSOPHILA EMBRYO
FUNCTION OF TORSO IN DETERMINING THE TERMINAL ANLAGEN OF THE DROSOPHILA EMBRYO
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DOI：
10.1038/335275a0
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发表时间：
1988-09-15
期刊：
影响因子：
64.8
通讯作者：
NUSSLEINVOLHARD, C
中科院分区：
文献类型：
--
作者：
KLINGLER, M;ERDELYI, M;NUSSLEINVOLHARD, C
果蝇、acron和telson的未分割末端区域的形成需要至少5个母系基因的功能（末端基因class1）。没有它们，就不会形成电枢和橡果。其中一个，躯干（tor）2，具有与功能缺失（tor -）等位基因表型相反的功能获得等位基因：幼虫体，胸部和腹部的节段区域缺失，而顶部不受影响，端部增大。在功能获得性强的突变体中，pair-rule genefushi tarazu3（ftz）不表达，这表明在发育的早期阶段，分割过程受到抑制。在具有合子遗传性无性的双突变体中，功能恢复效应被中和，片段被恢复，其表型与tor -相似（但不相同）。这表明，通过tll，并且在tor的功能获得等位基因中，tll基因产物在胚胎的中间位置异位表达，在那里它抑制了ftz等分割基因的表达。
The formation of the unsegmented terminal regions of theDrosophilalarva, acron and telson requires the function of at least five maternal genes (terminal genes class1). In their absence, the telson and acron are not formed. One of them,torso (tor)2, has gain-of-function alleles which have an opposite phenotype to the lack-of-function (tor–) alleles: the segmented regions of the larval body, thorax and abdomen, are missing, whereas the acron is not affected and the telson is enlarged. In strong gain-of-function mutants, the pair-rule genefushi tarazu3(ftz) is not expressed, demonstrating the suppression of the segmentation process in an early stage of development. Thetorgain-of-function effect is neutralized, and segmentation is restored in double mutants with the zygotic genetailless4,5(tll), which has a phenotype similar (but not identical) to that oftor–. This suggests thattoracts throughtll, and that in the gain-of-function alleles oftor, thetllgene product is ectopically expressed at middle positions of the embryo, where it inhibits the expression of segmentation genes likeftz.