Standardized uptake values for [18F] FDG in normal organ tissues: Comparison of whole-body PET/CT and PET/MRI
Standardized uptake values for [18F] FDG in normal organ tissues: Comparison of whole-body PET/CT and PET/MRI
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DOI：
10.1016/j.ejrad.2013.01.008
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发表时间：
2013-05-01
影响因子：
3.3
通讯作者：
Heusner, Till A.
中科院分区：
文献类型：
--
作者：
Heusch, Philipp;Buchbender, Christian;Heusner, Till A.
目的：比较[F-18]-脱氧葡萄糖(FDG)正电子发射断层扫描/磁共振成像(PET/MRI)和[F-18]-FDG正电子发射断层扫描/计算机断层扫描(PET/CT)在正常器官组织中的最大摄取值和平均摄取值。年龄57+/-13岁)常规全身FDG-PET/CT(注射290+/-40MBq[F-18]-FDG后60min)行全身PET/MRI检查(Magnetom Bioggraph MMR(TM)，西门子医疗，德国Erlangen)。在MRAC-PET和相应的CTAC-PET图像中，在7个生理器官部位手工绘制1.0 cm(3)的感兴趣体积。计算Spearman相关系数，比较基于MRAC和CTAC的SUV值；采用Wilcoxon配对符号等级检验进行潜在差异检验。结果：FDG-PET/CT与PET/MRI的平均延迟为92+/-18min。心肌的SUVmax/均值相关良好(R=0.97/0.97)，肝脏(R=0.65/0.72)、骨髓(R=0.42/0.41)和腰大肌的SUVmax(R=0.41)有较好的相关性。对于皮下脂肪，SUV平均值的相关系数为0.66(p<；0.05)。腰大肌的SUV平均值、皮下脂肪的SUVmax、肺的SUVmax和SUV平均值、血池的SUVmax和SUV平均值与MRAC和CTAC的相关性不显著。除心脏(SUVmax)和骨髓(SUVean)外，MRAC-PET的中位数SUVmax和SUV平均值均低于CTAC值(p<；0.05)。结论：在肿瘤患者行PET/CT和PET/MRI检查时，除肺、皮下脂肪和血池外，其他正常器官组织的SUVmax和SUV平均值与正常器官组织的SUVmax和SUV平均值基本相关。由PET/MRI得到的最大血流速度和平均血流速度可可靠地用于临床常规检查。(C)2013爱思唯尔爱尔兰有限公司。保留所有权利。
Purpose: To compare maximum and mean standardized uptake values (SUVmax/mean) of normal organ tissues derived from [F-18]-fluoro-desoxyglucose (FDG) positron emission tomography/magnetic resonance imaging (PET/MRI) using MR attenuation correction (MRAC) (DIXON-based 4-segment mu-map) with [F-18]-FDG positron emission tomography/computed tomography (PET/CT) using CT-based attenuation correction (CTAC).Methods and materials: In 25 oncologic patients (15 men, 10 women; age 57 +/- 13 years) after routine whole-body FDG-PET/CT (60 min after injection of 290 +/- 40 MBq [F-18]-FDG) a whole-body PET/MRI was performed (Magnetom Biograph mMR (TM), Siemens Healthcare, Erlangen, Germany). Volumes of interest of 1.0 cm(3) were drawn in 7 physiological organ sites in MRAC-PET and the corresponding CTAC-PET images manually. Spearman correlation coefficients were calculated to compare MRAC- and CTAC based SUV values; Wilcoxon-Matched-Pairs signed ranks test was performed to test for potential differences.Results: The mean delay between FDG-PET/CT and PET/MRI was 92 +/- 18 min. Excellent correlations of SUV values were found for the heart muscle (SUVmax/mean: R = 0.97/0.97); reasonably good correlations were found for the liver (R = 0.65/0.72), bone marrow (R = 0.42/0.41) and the SUVmax of the psoas muscle (R = 0.41). For subcutaneous fat, the correlation coefficient was 0.66 for SUVmean (p < 0.05). Correlations between MRAC and CTAC were non-significant for SUVmean of the psoas muscle, SUVmax of subcutaneous fat, SUVmax and SUVmean of the lungs, SUVmax and SUVmean of the blood-pool. The median SUVmax and SUVmean in MRAC-PET were lower than the respective CTAC values in all organs (p < 0.05) but heart (SUVmax) and the bone marrow (SUVmean).Conclusion: In conclusion, in oncologic patients examined with PET/CT and PET/MRI SUVmax and SUVmean values generally correlate well in normal organ tissues, except the lung, subcutaneous fat and the blood pool. SUVmax and SUVmean derived from PET/MRI can be used reliably in clinical routine. (C) 2013 Elsevier Ireland Ltd. All rights reserved.