Histological and temporal characteristics of nigral transneuronal degeneration after striatal injury
Histological and temporal characteristics of nigral transneuronal degeneration after striatal injury
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DOI：
10.1016/s0006-8993(98)00247-9
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发表时间：
1998-06
期刊：
影响因子：
2.9
通讯作者：
L. DeGiorgio;Christine Dibinis;T. Milner;M. Saji;B. Volpe
中科院分区：
文献类型：
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作者：
L. DeGiorgio;Christine Dibinis;T. Milner;M. Saji;B. Volpe
尾壳核和外侧苍白球的神经毒性损伤单侧引发同侧黑质网状体（SNR）神经元的跨神经元变性。使用无偏立体学对 SNR 神经元进行量化表明，神经元损失在最初纹状体损伤后 4 天开始，随后在第 6 天出现显着损失 (50%)，并在第 8 天达到稳定水平。光和超微结构水平的分析揭示了与一种程序性细胞死亡一致的形态变化。这些时间和组织学结果完善了体内模型，以探索延迟性神经元变性的机制。
Neurotoxic injury of the caudate-putamen and lateral globus pallidus unilaterally initiated transneuronal degeneration of neurons in the ipsilateral substantia nigra reticulata (SNR). Quantification of SNR neurons using unbiased stereology demonstrated that neuron loss began 4 days after the initial striatal lesion, followed by significant loss (50%) at 6 days and a plateau at 8 days. Analysis at the light and ultrastructural levels revealed morphological changes consistent with a type of programmed cell death. These temporal and histological results refine an in vivo model in which to explore mechanisms of delayed neuronal degeneration.