Calcium Release and Influx in Yeast: TRPC and VGCC Rule Another Kingdom
Calcium Release and Influx in Yeast: TRPC and VGCC Rule Another Kingdom
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DOI：
10.1126/stke.2002.127.pe17
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发表时间：
2002-04
期刊：
影响因子：
--
通讯作者：
Myriam Bonilla;K. Cunningham
中科院分区：
文献类型：
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作者：
Myriam Bonilla;K. Cunningham
钙是最普遍存在的第二信使之一，除了是许多蛋白质功能的重要辅助因子。因此，从真菌到植物再到动物的细胞都进化出了仔细控制细胞器和细胞质中钙浓度的机制。本文讨论了酵母和动物在瞬时受体电位通道（TRPC）和电压门控钙通道（VGCC）两大家族阳离子通道中的异同。突出的关键差异之一是在酵母和动物细胞对细胞内储存的钙耗尽的反应中涉及的通道，以及酵母和动物细胞之间这些通道的定位差异。因此，了解真菌钙离子通道的逻辑，可能会提供新的见解，在动物细胞钙信号网络的组织和调节。
Calcium is one of the most ubiquitous second messengers, in addition to being a fundamentally important cofactor for many proteins' functions. Thus, cells from fungi to plants to animals have evolved mechanisms for carefully controlling calcium concentrations in their organelles and cytosol. This perspective discusses the similarities and differences between yeast and animals in cation channels of two families: the transient receptor potential channels (TRPCs) and voltage-gated calcium channels (VGCCs). One of the key differences highlighted is in the channels implicated in the response of yeast and animal cells to depletion of calcium from intracellular stores, and the differences in localization of these channels between yeast and animal cells. Understanding the logic of fungal Ca2+ channels, therefore, may provide new insights into the organization and regulation of cellular calcium signaling networks in animals.