Hypothalamic substance P release. Attenuated angiotensin responses in mRen2(27) transgenic rats.
Hypothalamic substance P release. Attenuated angiotensin responses in mRen2(27) transgenic rats.
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DOI：
10.1161/01.hyp.29.1.510
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发表时间：
1997
期刊：
影响因子：
8.3
通讯作者：
D. Diz;B. Falgui;S. Bosch;B. Westwood;J. Kent;D. Ganten;C. Ferrario
中科院分区：
文献类型：
--
作者：
D. Diz;B. Falgui;S. Bosch;B. Westwood;J. Kent;D. Ganten;C. Ferrario
在mRen2(27)肾素转基因[TG(+)]大鼠中，脑室内注射血管紧张素肽引起的动脉压和室旁核血管加压素释放的增加是钝化的。脑室注射速激肽可以模拟血管紧张素肽的几种作用，血管紧张素肽能刺激下丘脑脑片释放P物质。本研究评估了血管紧张素肽对TG(+)大鼠P物质释放的影响。8-12周龄平均收缩压为197+/-4 mm Hg(n=20；P<0.05)。血管紧张素-(1-7)和血管紧张素II显著增加TG(-)大鼠下丘脑P物质的释放(分别比对照组高出82%和70%：P<；0.05)，但对TG(+)大鼠无明显影响。这些研究进一步支持了这样的假设，即血管紧张素肽的心血管效应部分是由P物质介导的，并且这种关系在高血压模型中被钝化，该模型是由血管紧张素的过度组织产生造成的。
Increases in arterial pressure and paraventricular nucleus vasopressin release in response to intracerebroventricular injections of angiotensin peptides are blunted in mRen2(27) renin transgenic [TG(+)] rats. Intraventricular injections of tachykinin peptides mimic several of the actions of angiotensin peptides, and angiotensin peptides evoke substance P release from hypothalamic brain slices. The present study assessed whether diminished substance P release occurs in response to angiotensin peptides in TG(+) rats. Systolic blood pressure at 8 to 12 weeks of age averaged 197 +/- 4 mm Hg (n = 20; P .05). Angiotensin-(1-7) and angiotensin II significantly increased substance P release from hypothalamus of TG(-) rats (82% and 70% above control: P < .05) but not TG(+) rats. These studies further support the hypothesis that the cardiovascular effects of angiotensin peptides are mediated in part by substance P and that this relationship is blunted in a hypertensive model that results from excess tissue production of angiotensins.