Drosophila melanogaster as a model for lead neurotoxicology and toxicogenomics research.
Drosophila melanogaster as a model for lead neurotoxicology and toxicogenomics research.
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DOI：
10.3389/fgene.2012.00068
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发表时间：
2012
影响因子：
3.7
通讯作者：
Ruden DM
中科院分区：
文献类型：
--
作者：
Hirsch HV;Lnenicka G;Possidente D;Possidente B;Garfinkel MD;Wang L;Lu X;Ruden DM
黑腹果蝇是研究铅神经毒理学的良好模型动物。从古罗马时代起就知道，长期接触低水平的铅会导致行为异常，如现在所知的注意力缺陷多动障碍(ADHD)。由于铅改变了构成发育神经元可塑性的机制，儿童长期接触铅，即使血铅水平低于当前疾控中心社区行动水平(10μg/dl)，也会导致认知能力下降、犯罪可能性增加、与多动症相关的行为、活动水平改变、感觉功能改变、女孩性成熟延迟以及免疫功能改变。为了更好地了解铅如何影响神经元可塑性，我们将介绍果蝇行为遗传学实验室、果蝇神经生理学实验室和果蝇数量遗传学实验室的最新发现，这些实验室联手研究铅对果蝇神经系统的影响。研究铅对果蝇神经系统发育的影响，将有助于我们更好地了解铅在人类神经系统发育中的神经毒性机制。
Drosophila melanogaster is an excellent model animal for studying the neurotoxicology of lead. It has been known since ancient Roman times that long-term exposure to low levels of lead results in behavioral abnormalities, such as what is now known as attention deficit hyperactivity disorder (ADHD). Because lead alters mechanisms that underlie developmental neuronal plasticity, chronic exposure of children, even at blood lead levels below the current CDC community action level (10 μg/dl), can result in reduced cognitive ability, increased likelihood of delinquency, behaviors associated with ADHD, changes in activity level, altered sensory function, delayed onset of sexual maturity in girls, and changes in immune function. In order to better understand how lead affects neuronal plasticity, we will describe recent findings from a Drosophila behavioral genetics laboratory, a Drosophila neurophysiology laboratory, and a Drosophila quantitative genetics laboratory who have joined forces to study the effects of lead on the Drosophila nervous system. Studying the effects of lead on Drosophila nervous system development will give us a better understanding of the mechanisms of Pb neurotoxicity in the developing human nervous system.