DNA double strand break repair via non-homologous end-joining.
DNA double strand break repair via non-homologous end-joining.
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DOI：
10.3978/j.issn.2218-676x.2013.04.02
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发表时间：
2013-06
影响因子：
0.9
通讯作者：
Chen DJ
中科院分区：
文献类型：
--
作者：
Davis AJ;Chen DJ
DNA双链断裂（DSB）是最危险的DNA损伤形式之一。未修复的DSB导致细胞发生凋亡或衰老，而DSB的错误加工可导致基因组不稳定和致癌。真核细胞中负责DSB修复的一个重要途径是非同源末端连接（NHEJ）。在这篇综述中，我们将讨论有趣的新见解的机制NHEJ途径和蛋白质介导这一修复过程。此外，将讨论NHEJ在促进基因组稳定性方面的一般作用。
DNA double-stranded breaks (DSB) are among the most dangerous forms of DNA damage. Unrepaired DSBs results in cells undergoing apoptosis or senescence whereas mis-processing of DSBs can lead to genomic instability and carcinogenesis. One important pathway in eukaryotic cells responsible for the repair of DSBs is non-homologous end-joining (NHEJ). In this review we will discuss the interesting new insights into the mechanism of the NHEJ pathway and the proteins which mediate this repair process. Furthermore, the general role of NHEJ in promoting genomic stability will be discussed.