Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism
Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism
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DOI：
10.1016/s1074-7613(00)00004-2
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发表时间：
2000-07-01
期刊：
影响因子：
32.4
通讯作者：
Grosschedl, R
中科院分区：
文献类型：
--
作者：
Reya, T;O'Riordan, M;Grosschedl, R
Lymphocyte enhancer factor-1 (LEF-1) is a member of the LEF-1/TCF family of transcription factors, which have been implicated in Wnt signaling and tumorigenesis. LEF-1 was originally identified in pre-B and T cells, but its function in B lymphocyte development remains unknown. Here we report that LEF-1-deficient mice exhibit defects in pro-B cell proliferation and survival in vitro and in vivo. We further show that Lef1(-/-) pro-B cells display elevated levels of fas and c-myc transcription, providing a potential mechanism for their increased sensitivity to apoptosis. Finally, we establish a link between Wnt signaling and normal B cell development by demonstrating that Wnt proteins are mitogenic for pro-B cells and that this effect is mediated by LEF-1.
