Role of Genetic and Acquired Prothrombotic Risk Factors in Genesis of Sudden Sensorineural Hearing Loss
Role of Genetic and Acquired Prothrombotic Risk Factors in Genesis of Sudden Sensorineural Hearing Loss
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DOI：
10.1159/000319310
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发表时间：
2011-01-01
影响因子：
1.6
通讯作者：
de Vincentiis, Marco
中科院分区：
文献类型：
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作者：
Fusconi, Massimo;Chistolini, Antonio;de Vincentiis, Marco
对40例突发性感音神经性聋(SSHL)患者进行了亚甲基四氢叶酸还原酶C677T突变、凝血因子V G1691A(F V Leiden)突变、凝血酶原G20210A突变等8项实验室指标分析。这些结果与120名未受SSHL影响的对照组的结果进行了比较。我们发现SSHL组高同型半胱氨酸血症的发生率显著高于对照组，这也与MTHFR C677T突变纯合子的存在有关。研究结果表明，在其他因素中，SSHL可能是由这两个变量的组合引起的。我们建议对MTHFR C677T突变的分析应进一步研究以确定SSHL的病因，对于同型半胱氨酸水平高的患者也应考虑同样的分析。版权所有(C)2010 S.Karger AG，巴塞尔
The methylenetetrahydrofolate reductase C677T mutation, factor V G1691A (factor V Leiden) mutation, prothrombin G20210A mutation and 8 other laboratory values associated with increased thrombotic risk were analyzed in 40 patients with sudden sensorineural hearing loss (SSHL). The results were compared with those obtained from 120 controls not affected by SSHL. We found a statistically significant higher frequency of hyperhomocysteinemia in the SSHL group compared with controls, and that this was also associated with the presence of homozygosity for the MTHFR C677T mutation. The study results suggest that SSHL might be caused, among other factors, by a combination of these 2 variables. We suggest that this analysis of the MTHFR C677T mutation should be further investigated to establish the etiology of SSHL, and that the same analysis should be taken into account in those patients with high levels of homocysteine. Copyright (C) 2010 S. Karger AG, Basel