The analgesic response to stress: genetic and gender considerations.
The analgesic response to stress: genetic and gender considerations.
复制标题
对压力的镇痛反应：遗传和性别考虑。
DOI：
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
J. Liebeskind
中科院分区：
文献类型：
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作者：
W. Sternberg;J. Liebeskind
大脑包含神经元回路，通过电刺激或环境应激激活神经元回路可引起镇痛。阿片样物质和非阿片样物质形式的刺激诱导的镇痛存在，并在解剖学上区分。几种递质已被假定为非阿片样物质刺激诱导的镇痛，N-甲基-D-天冬氨酸是一个特别可能的候选人。在小鼠中有显着的性别差异，在潜在的神经化学药物的压力引起的镇痛，其发展是敏感的激素环境在出生后早期的发展，并随着年龄的变化在两种性别。老鼠可以被培育成对压力有高或低的镇痛反应，有证据表明这是由一个单一的基因决定的。手术疼痛，作为一种应激源，抑制自然杀伤（NK）细胞的活性和影响的倾向发展转移时，小鼠接种实验肿瘤腹部手术后。这可能会受到围手术期吗啡镇痛剂量的影响。
The brain contains neuronal circuits, activation of which by electrical stimulation or environmental stress causes analgesia. Both opioid and non-opioid forms of stimulus-induced analgesia exist, and are anatomically differentiated. Several transmitters have been postulated for non-opioid stimulus-induced analgesia, N-methyl-D-aspartic acid being a particularly likely candidate. In mice there are marked gender differences in the underlying neurochemical medication of stress-induced analgesia, the development of which is sensitive to the hormonal environment during early post-natal development and which changes with age in both sexes. Mice can be bred for a high or low analgesic response to stress and there is evidence that this is determined by a single gene. Operative pain, as a stressor, inhibits natural killer (NK) cell activity and influences the propensity to develop metastases when mice are inoculated with an experimental tumour after abdominal surgery. This can be influenced by peri-operative morphine in analgesic doses.