Ultraviolet light and cutaneous lupus
Ultraviolet light and cutaneous lupus
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DOI：
10.1177/0961203306071705
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发表时间：
2006-01-01
期刊：
影响因子：
2.6
通讯作者：
Kallenberg, Cees G. M.
中科院分区：
文献类型：
--
作者：
Bijl, Marc;Kallenberg, Cees G. M.
暴露于紫外线（UV）光是已知的触发（系统性）红斑狼疮患者皮肤疾病活动的主要因素之一。紫外线，尤其是UVB，是一种有效的细胞凋亡诱导剂。目前，凋亡细胞的清除紊乱是解释狼疮患者炎症发展的概念之一。我们综述了凋亡细胞和自身抗体在UVB诱导的皮肤病变发病机制中的作用。
Exposure to ultraviolet (UV) light is one of the major factors known to trigger cutaneous disease activity in (systemic) lupus erythematosus patients. UV light, UVB in particular, is a potent inducer of apoptosis. Currently, disturbed clearance of apoptotic cells is one of the concepts explaining the development of inflammation in lupus patients. We review the role of apoptotic cells and autoantibodies in the pathogenesis of UVB induced skin lesions.