Interactions between alcohol and the HIV entry inhibitor Maraviroc.
Interactions between alcohol and the HIV entry inhibitor Maraviroc.
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DOI：
10.1177/2325957413495567
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发表时间：
2013-11
影响因子：
--
通讯作者：
McCance-Katz EF
中科院分区：
文献类型：
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作者：
Gruber VA;Rainey PM;Lum PJ;Beatty GW;Aweeka FT;McCance-Katz EF
酒精使用在艾滋病毒感染者中很常见，并且关于酒精与药物相互作用的信念预示着药物依从性降低，有耐药性突变的风险。马拉维克是一种HIV进入抑制剂，被批准用于治疗药物敏感和耐药的HIV毒株。本研究评估了酒精对马拉韦洛克药代动力学的影响，以及马拉韦洛克对酒精药代动力学的影响。10名健康成人在给药7天前后分别完成了酒精（1 g/kg）和安慰剂酒精药代动力学试验。服用马拉韦洛克后，酒精浓度增加了12%。马拉韦洛克的药代动力学不受酒精影响。如果饮酒，不应中断马拉韦洛克的治疗。
Alcohol use is common among people with HIV, and beliefs about alcohol interactions with medications predict decreased medication adherence, risking drug-resistant mutations. Maraviroc is an HIV entry inhibitor approved for treatment of both drug-sensitive and drug-resistant HIV strains. The present study evaluated the effects of alcohol on maraviroc pharmacokinetics, and of maraviroc on alcohol pharmacokinetics. Ten healthy adults completed alcohol (1 g/kg) and placebo alcohol pharmacokinetics sessions before and after 7 days of maraviroc administration. Alcohol concentrations increased 12% following maraviroc. Maraviroc pharmacokinetics were unaffected by alcohol. Maraviroc treatment should not be interrupted if alcohol is consumed.