Epigenetic Regulation of Gene Expression Induced by Butyrate in Colorectal Cancer: Involvement of MicroRNA.
Epigenetic Regulation of Gene Expression Induced by Butyrate in Colorectal Cancer: Involvement of MicroRNA.
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DOI：
10.1177/1179237x17729900
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发表时间：
2017
影响因子：
--
通讯作者：
Marlow G
中科院分区：
文献类型：
--
作者：
Bishop KS;Xu H;Marlow G
结直肠癌（CRC）是全球第三大癌症死亡原因。结直肠癌的发生与生活方式密切相关，饮食可能会调节风险。西式饮食的特点是大量摄入红肉，但很少摄入水果、蔬菜和全麦食品。这种饮食习惯与结直肠癌风险相关。已经证明，膳食植物纤维发酵产生的丁酸盐可以改变遗传和表观遗传表达。 MicroRNA (miRNA) 是一种小型非编码 RNA，通常存在于正常细胞和肿瘤细胞中。异常的 miRNA 表达与 CRC 的发生、进展和转移有关。此外，丁酸盐还可调节 CRC 中的细胞增殖、分化、凋亡和 miRNA 表达。在这篇综述中，我们将讨论丁酸盐对调节 CRC 中 miRNA 表达的影响。此外，还将提供丁酸盐通过减少致癌 miRNA 表达来影响 CRC 风险的证据。
Colorectal cancer (CRC) is the third most common cause of cancer mortality globally. Development of CRC is closely associated with lifestyle, and diet may modulate risk. A Western-style diet is characterised by a high intake of red meat but low consumption of fruit, vegetables, and whole cereals. Such a diet is associated with CRC risks. It has been demonstrated that butyrate, produced by the fermentation of dietary plant fibre, can alter both genetic and epigenetic expressions. MicroRNAs (miRNAs) are small non-coding RNAs that are commonly present in both normal and tumour cells. Aberrant miRNA expression is associated with CRC initiation, progression, and metastasis. In addition, butyrate can modulate cell proliferation, differentiation, apoptosis, and miRNA expression in CRC. In this review, the effects of butyrate on modulating miRNA expression in CRC will be discussed. Furthermore, evidence on the effect of butyrate on CRC risk through reducing oncogenic miRNA expression will be presented.