CELL FATE IN THE DROSOPHILA OMMATIDIUM
CELL FATE IN THE DROSOPHILA OMMATIDIUM
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DOI：
10.1016/0012-1606(87)90448-9
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发表时间：
1987-09-01
影响因子：
2.7
通讯作者：
READY, DF
中科院分区：
文献类型：
--
作者：
TOMLINSON, A;READY, DF
果蝇基因sevenless的损伤导致通常注定要分化为小眼的感光细胞7的细胞变成了分泌副晶状体的细胞，即赤道锥细胞。在P元件和EMS诱导的等位基因中，发育转化发生相同。突变是细胞自主的，表明发育失败是转化细胞固有的。组织学和免疫学分析表明，细胞未能操作任何感光细胞分化机制之前，采用视锥细胞途径。
Lesions in the Drosophila gene sevenless cause the cell normally destined to differentiate as photoreceptor 7 of the ommatidium to become an accessory lens-secreting cell, the equatorial cone cell. In both P-element- and EMS-induced alleles, the developmental transformation occur identically. The mutation is cell autonomous, showing that the developmental failure is intrinsic to the transformed cell. Histological and immunological analyses indicate that the cell fails to operate any photoreceptor differentiation machinery prior to adopting the cone cell pathway.